[HTML][HTML] Salidroside alleviates cognitive impairment by inhibiting ferroptosis via activation of the Nrf2/GPX4 axis in SAMP8 mice

S Yang, L Wang, Y Zeng, Y Wang, T Pei, Z Xie, Q Xiong… - Phytomedicine, 2023 - Elsevier
Background Alzheimer's disease (AD) is a neurogenerative disease and remains no
effective method for stopping its progress. Ferroptosis and adaptive immunity have been …

[HTML][HTML] Salidroside attenuates neuronal ferroptosis by activating the Nrf2/HO1 signaling pathway in Aβ1-42-induced Alzheimer's disease mice and glutamate-injured …

S Yang, Z Xie, T Pei, Y Zeng, Q Xiong, H Wei, Y Wang… - Chinese Medicine, 2022 - Springer
Background Alzheimer's disease (AD) is a neurodegenerative disease. Ferroptosis plays a
critical role in neurodegenerative diseases. Nuclear factor E2-related factor 2 (Nrf2) is …

[HTML][HTML] Forsythoside a mitigates alzheimer's-like pathology by inhibiting ferroptosis-mediated neuroinflammation via Nrf2/GPX4 axis activation

C Wang, S Chen, H Guo, H Jiang, H Liu… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Ferroptosis and neuroinflammation play crucial roles in Alzheimer's disease (AD)
pathophysiology. Forsythoside A (FA), the main constituent of Forsythia suspensa (Thunb.) …

[HTML][HTML] Salidroside Mediated the Nrf2/GPX4 Pathway to Attenuates Ferroptosis in Parkinson's Disease

J Shen, S Chen, X Li, L Wu, X Mao, J Jiang… - Neurochemical …, 2024 - Springer
Parkinson's Disease (PD) is characterized by the loss of dopaminergic neurons, with
ferroptosis playing a significant role. Salidroside (SAL) has shown neuroprotective potential …

Berberine ameliorates iron levels and ferroptosis in the brain of 3× Tg-AD mice

X Li, J Chen, W Feng, C Wang, M Chen, Y Li, J Chen… - Phytomedicine, 2023 - Elsevier
Background Berberine (BBR) is a natural alkaloid extracted from the herb Coptis chinensis.
This compound has the ability to penetrate the blood-brain barrier (BBB) and exhibit …

[HTML][HTML] Astragaloside IV mitigates cerebral ischaemia-reperfusion injury via inhibition of P62/Keap1/Nrf2 pathway-mediated ferroptosis

L Wang, C Liu, L Wang, B Tang - European journal of pharmacology, 2023 - Elsevier
Cerebral ischaemia-reperfusion injury (CIRI) is a critical component of ischaemic stroke
pathogenesis. Ferroptosis contributes to and aggravates CIRI, whereas the P62/Kelch-like …

Dimethyl fumarate improves cognitive deficits in chronic cerebral hypoperfusion rats by alleviating inflammation, oxidative stress, and ferroptosis via NRF2/ARE/NF-κB …

N Yan, Z Xu, C Qu, JJ Zhang - International Immunopharmacology, 2021 - Elsevier
Cerebrovascular disease and its risk factors cause persistent decrease of cerebral blood
flow, chronic cerebral hypoperfusion (CCH) is the major foundation of vascular cognitive …

Angong Niuhuang Wan inhibit ferroptosis on ischemic and hemorrhagic stroke by activating PPARγ/AKT/GPX4 pathway

X Bai, E Zheng, L Tong, Y Liu, X Li, H Yang… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Angong Niuhuang Wan (AGNHW) is a
prescription from traditional Chinese medicine (TCM) that has been used for centuries to …

[HTML][HTML] Astragaloside IV attenuates ferroptosis after subarachnoid hemorrhage via Nrf2/HO-1 signaling pathway

Z Liu, Z Zhou, P Ai, C Zhang, J Chen… - Frontiers in …, 2022 - frontiersin.org
Subarachnoid hemorrhage (SAH) is a severe type of stroke featuring exceptionally high rate
of morbidity and mortality due to the lack of effective management. Ferroptosis can be …

[HTML][HTML] Kaempferol ameliorates oxygen-glucose deprivation/reoxygenation-induced neuronal ferroptosis by activating Nrf2/SLC7A11/GPX4 axis

Y Yuan, Y Zhai, J Chen, X Xu, H Wang - Biomolecules, 2021 - mdpi.com
Kaempferol has been shown to protect cells against cerebral ischemia/reperfusion injury
through inhibition of apoptosis. In the present study, we sought to investigate whether …