This investigation was conducted to determine the relationship between Y chromosome loss
and increased micronucleus formation with age. We also investigated the status of …

From the fertilization of an egg until the death of an individual, somatic cells can accumulate
genetic changes, such that cells from different tissues or even within the same tissue differ …

Background X&Y chromosomal aneuploidies are among the most common human whole-
chromosomal copy number changes, but the population-based incidence and prevalence in …

Amplicons—large, highly identical segmental duplications—are a prominent feature of
mammalian Y chromosomes. Although they encode genes essential for fertility, these …

Context.—The clinical association between loss of the Y chromosome and acute
myelogenous leukemia and myelodysplastic syndrome (AML/MDS) has been debated …

In PNAS, Krementsov et al.(1) report that if you are a male mouse and catch the flu, the
severity of your illness may depend on the type of Y chromosome (ChrY) that you have. In …

The human Y-chromosome does not recombine across its male-specific part and is therefore
an excellent marker of human migrations. It also plays an important role in male fertility …

Male-specific Y-chromosome (chrY) polymorphisms are interesting components of the DNA
for population genetics. While single nucleotide polymorphisms (Y-SNPs) indicate distant …

At every age, males have a higher risk of mortality than do females. This sex difference is
most often attributed to the usual suspects: differences in hormones and life experiences …

Background Understanding the impact of clonal hematopoiesis of indeterminate potential
(CHIP) and mosaic chromosomal alterations (mCAs) on solid tumor risk and mortality can …