New concepts in the generation and functions of IgA
O Pabst - Nature Reviews Immunology, 2012 - nature.com
The intestinal mucosa contains the largest population of antibody-secreting plasma cells in
the body, and in humans several grams of secretory immunoglobulin A (SIgA) are released …
the body, and in humans several grams of secretory immunoglobulin A (SIgA) are released …
[HTML][HTML] IgA and the intestinal microbiota: the importance of being specific
Secretory IgA has long been a divisive molecule. Some immunologists point to the mild
phenotype of IgA deficiency to justify ignoring it, while some consider its abundance and …
phenotype of IgA deficiency to justify ignoring it, while some consider its abundance and …
[HTML][HTML] Roles of secretory immunoglobulin A in host-microbiota interactions in the gut ecosystem
ED León, MP Francino - Frontiers in Microbiology, 2022 - frontiersin.org
In the gastrointestinal tract (GIT), the immune system interacts with a variety of
microorganisms, including pathogens as well as beneficial symbionts that perform important …
microorganisms, including pathogens as well as beneficial symbionts that perform important …
[HTML][HTML] Secretory IgA in intestinal mucosal secretions as an adaptive barrier against microbial cells
B Pietrzak, K Tomela, A Olejnik-Schmidt… - International journal of …, 2020 - mdpi.com
Secretory IgA (SIgA) is the dominant antibody class in mucosal secretions. The majority of
plasma cells producing IgA are located within mucosal membranes lining the intestines …
plasma cells producing IgA are located within mucosal membranes lining the intestines …
[HTML][HTML] Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut
NJ Mantis, N Rol, B Corthésy - Mucosal immunology, 2011 - nature.com
Abstract Secretory IgA (SIgA) serves as the first line of defense in protecting the intestinal
epithelium from enteric toxins and pathogenic microorganisms. Through a process known as …
epithelium from enteric toxins and pathogenic microorganisms. Through a process known as …
Regulation of IgA synthesis at mucosal surfaces
S Fagarasan, T Honjo - Current opinion in immunology, 2004 - Elsevier
Immunoglobulin A is the main element of the humoral immune response that has been
selected through evolution, together with innate mucosal defences, to provide protection …
selected through evolution, together with innate mucosal defences, to provide protection …
Intestinal IgA synthesis: regulation of front-line body defences
S Fagarasan, T Honjo - Nature Reviews Immunology, 2003 - nature.com
Immunoglobulin A is the most abundant immunoglobulin isotype in mucosal secretions. In
this review, we summarize recent advances in our understanding of the sites, mechanisms …
this review, we summarize recent advances in our understanding of the sites, mechanisms …
[HTML][HTML] IgA in human health and diseases: Potential regulator of commensal microbiota
T Takeuchi, H Ohno - Frontiers in Immunology, 2022 - frontiersin.org
Gut microbiota has extensive and tremendous impacts on human physiology and pathology.
The regulation of microbiota is therefore a cardinal problem for the mutualistic relationship …
The regulation of microbiota is therefore a cardinal problem for the mutualistic relationship …
IgA synthesis: a form of functional immune adaptation extending beyond gut
DB Sutherland, S Fagarasan - Current opinion in immunology, 2012 - Elsevier
Immunoglobulin A (IgA) is the most abundantly produced antibody isotype in mammals. The
primary function of IgA is to maintain homeostasis at mucosal surfaces. IgA is generated in …
primary function of IgA is to maintain homeostasis at mucosal surfaces. IgA is generated in …