Complex and diverse communities of bacteria establish mutualistic and symbiotic
relationships with the gut after birth. The intestinal immune system responds to bacterial …

While the gut epithelium represents the largest mucosal tissue, the mechanisms underlying
the interaction between intestinal bacteria and the host epithelium lead to multiple outcomes …

The gut harbors an extremely dense and complex community of microorganisms that are in
constant dialog with our immune cells. The gut bacteria provide strong selective pressure to …

Our intestine is colonized by an impressive community of bacteria, that has profound effects
on the immune functions. The relationship between gut microbiota and the immune system …

Among antibodies, IgA is unique because it has evolved to be secreted onto mucosal
surfaces. The structure of IgA and the associated secretory component allow IgA to survive …

Most antibodies produced in the body are of the IgA class. The dominant cell population
producing them are plasma cells within the lamina propria of the gastrointestinal tract, but …

The human intestine is densely colonized with commensal microbes that stimulate the
immune system. While secretory Immunoglobulin (Ig) A is known to play a crucial role in gut …

An important activity of mucosal surfaces is the production of antibodies (Abs) referred to as
secretory immunoglobulin A (SIgA) that serve as a first line of defense to repel pathogenic …

Intestinal bacteria outnumber our own human cells in conditions of both health and disease.
It has long been recognized that secretory antibody, particularly IgA, is produced in …

In mammals, the gut is populated with an extremely dense and diverse bacterial community.
One response following intestinal colonization is the production of immunoglobulin (Ig) A by …