The therapeutic effects induced by serotonin-selective reuptake inhibitor (SSRI)
antidepressants are initially triggered by blocking the serotonin transporter and rely on long …

Since its discovery 50 years ago, the role of the indoleamine 5‐HT (5‐hydroxytryptamine;
serotonin) in the pathogenesis of depression and in the mechanism of action of …

The serotonin (5-hydroxytryptamine2C [5-HT2C]) receptor is one of the 5-HT receptors with
a G-protein-coupled intracellular signalling pathway. A large number of compounds showing …

The neurotransmitter serotonin (5-hdroxytryptamine; 5-HT) has been implicated in the
pathophysiology and treatment of major depression since the serendipitous discovery of …

5-HT1B receptors are expressed throughout the mammalian central nervous system. These
receptors are located in the axon terminals of both serotonergic and nonserotonergic …

Numerous observations support the notion that serotonin (5-hydroxytryptamine; 5-HT) and
its multiple receptor subtypes are linked not only to the biological basis of depression, but …

The serotonergic (5-HT) system has been widely implicated in the pathophysiology of Major
Depressive Disorder (MDD). Although the 5-HT system is a popular target for drug therapy in …

Abstract Rationale Serotonin reuptake inhibitors (SSRIs) are effective in treating depression.
Given the existence of different families and subtypes of 5-HT receptors, multiple 5-HT …

Serotonin (5-hydroxytryptamine, 5-HT) is implicated in several psychiatric diseases. Is this
also true for 5-HT1B/D receptors? These receptors are found in high density in substantia …

Serotonin (5-HT) 3 receptors are the only ligand-gated ion channel of the 5-HT receptors
family. They are present both in the peripheral and central nervous system and are localized …