[HTML][HTML] Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities

ED Mock, B Gagestein, M van der Stelt - Progress in Lipid Research, 2023 - Elsevier
Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …

[HTML][HTML] Endocannabinoids and related N-acylethanolamines: biological activities and metabolism

K Tsuboi, T Uyama, Y Okamoto, N Ueda - Inflammation and Regeneration, 2018 - Springer
The plant Cannabis sativa contains cannabinoids represented by Δ 9-tetrahydrocannabinol,
which exert psychoactivity and immunomodulation through cannabinoid CB1 and CB2 …

Biological functions and metabolism of oleoylethanolamide

C Thabuis, D Tissot-Favre, JB Bezelgues, JC Martin… - Lipids, 2008 - Springer
The present review is focused on the metabolism and the emerging roles of
oleoylethanolamide (OEA) with emphasis on its effects on food intake control and lipid …

Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice

ED Mock, M Mustafa, O Gunduz-Cinar, R Cinar… - Nature chemical …, 2020 - nature.com
Abstract N-acylethanolamines (NAEs), which include the endocannabinoid anandamide,
represent an important family of signaling lipids in the brain. The lack of chemical probes …

Pathways and mechanisms of N-acylethanolamine biosynthesis: can anandamide be generated selectively?

HHO Schmid - Chemistry and physics of lipids, 2000 - Elsevier
Long-chain N-acylethanolamines (NAEs) and their precursors, N-acylethanolamine
phospholipids, are ubiquitous trace constituents of animal and human cells, tissues and …

[HTML][HTML] N-Acyl Amino Acids: Metabolism, Molecular Targets, and Role in Biological Processes

N Battista, M Bari, T Bisogno - Biomolecules, 2019 - mdpi.com
The lipid signal is becoming increasingly crowded as increasingly fatty acid amide
derivatives are being identified and considered relevant therapeutic targets. The …

New insights into endocannabinoid degradation and its therapeutic potential

M Bari, N Battista, F Fezza, V Gasperi… - Mini reviews in …, 2006 - ingentaconnect.com
Endocannabinoids are amides, esters and ethers of long chain polyunsaturated fatty acids,
which act as new lipidic mediators. Anandamide (N-arachidonoylethanolamine; AEA) and 2 …

The N-acylation-phosphodiesterase pathway and cell signalling

HHO Schmid, PC Schmid, V Natarajan - Chemistry and physics of lipids, 1996 - Elsevier
Long-chain N-acylethanolamines (NAEs) elicit a variety of biological and pharmacological
effects, Anandamide (20: 4n-6 NAE) and other polyunsaturated NAEs bind to the …

Inactivation of N-Acyl Phosphatidylethanolamine Phospholipase D Reveals Multiple Mechanisms for the Biosynthesis of Endocannabinoids

D Leung, A Saghatelian, GM Simon, BF Cravatt - Biochemistry, 2006 - ACS Publications
N-Acyl ethanolamines (NAEs) constitute a large and diverse class of signaling lipids that
includes the endogenous cannabinoid anandamide. Like other lipid transmitters, NAEs are …

Cannabinoid receptor-inactive N-acylethanolamines and other fatty acid amides: metabolism and function

HHO Schmid, EV Berdyshev - Prostaglandins, Leukotrienes and Essential …, 2002 - Elsevier
Although it is now generally accepted that long-chain N-acylethanolamines and their
precursors, N-acylethanolamine phospholipids, exist as trace constituents in virtually all …