Isoprenaline stimulated increases in ornithine decarboxylase activity and polyamine content
in cardiac tissues are implicated in macromolecular synthesis and cellular growth, but little is …

Polyamines are thought to play an essential role in cellular hypertrophy and proliferation.
Ornithine decarboxylase (ODC) catalyzes the first and probably the rate-limiting step in …

Ornithine decarboxylase, a possible rate-limiting enzyme in the synthesis of polyamines,
was assayed in hearts of normal rats, sham-operated rats, and rats subjected to aortic …

Two lines of transgenic mice were produced with constitutive expression of antizyme-1 in the
heart, driven from the cardiac α-myosin heavy chain promoter. The use of engineered …

Rats were treated with a single dose of isoproterenol (25 mg/kg sc) and the levels of
polyamines determined in various parts (right ventricle, basis, medial part and apex of the …

To evaluate the role of polyamine biosynthesis in myocardial growth, the activity of ornithine
decarboxylase (ODC) and the levels of the polyamines, spermidine, spermine, and …

Ornithine decarboxylase (ODC, EC 4.1. 1.7), a rate-limiting enzyme in polyamine
biosynthesis, is known to be induced by a beta-adrenoceptor agonist, isoproterenol (ISO) …

DFMO is a selective irreversible inhibitor of ornithine decarboxylase (ODC), the initial
enzyme in the polyamine biosynthetic pathway. DFMO was utilized to determine the role of …

An acute treatment of mice with clenbuterol, a β-adrenergic agonist, produced a marked
increase of polyamines levels in heart, particularly during the early phase of administration …

Ornithine decarboxylase activities (ODC) and polyamine levels were determined in five
cardiac regions of the rat heart, following daily administration of 1 mg/kg of thyroxine, in the …