Highlights•Secretory immunoglobulin A (SIgA) is the dominant antibody at mucosal
surfaces.•Gut commensals are coated by SIgA at varied levels.•SIgA targeting regulates …

In the gastrointestinal tract (GIT), the immune system interacts with a variety of
microorganisms, including pathogens as well as beneficial symbionts that perform important …

The intestinal mucosa contains the largest population of antibody-secreting plasma cells in
the body, and in humans several grams of secretory immunoglobulin A (SIgA) are released …

Mucosal surfaces in the gastrointestinal tract are continually exposed to native, commensal
antigens and susceptible to foreign, infectious antigens. Immunoglobulin A (IgA) provides …

The human intestine is densely colonized with commensal microbes that stimulate the
immune system. While secretory Immunoglobulin (Ig) A is known to play a crucial role in gut …

Secretory immunoglobulin A (SIgA) regulates the composition and function of the gut
microbiota and modulates its interaction with the host, but how this regulation is achieved is …

Immunoglobulin A (IgA) is the most abundant antibody at mucosal surfaces and has been
the subject of many investigations involving microbiota research in the last decade. Although …

Gut microbiota has extensive and tremendous impacts on human physiology and pathology.
The regulation of microbiota is therefore a cardinal problem for the mutualistic relationship …

Among antibodies, IgA is unique because it has evolved to be secreted onto mucosal
surfaces. The structure of IgA and the associated secretory component allow IgA to survive …

Antibodies are key elements of protective immunity. In the mucosal immune system in
particular, secretory immunoglobulin A (SIgA), the most abundantly produced antibody …