In vitro and in vivo models: What have we learnt about inner ear regeneration and treatment for hearing loss?
MP Lee, J Waldhaus - Molecular and Cellular Neuroscience, 2022 - Elsevier
The sensory cells of the inner ear, called hair cells, do not regenerate spontaneously and
therefore, hair cell loss and subsequent hearing loss are permanent in humans. Conversely …
therefore, hair cell loss and subsequent hearing loss are permanent in humans. Conversely …
Novel insights into inner ear development and regeneration for targeted hearing loss therapies
Sensorineural hearing loss is the most common sensory deficit in humans. Despite the
global scale of the problem, only limited treatment options are available today. The …
global scale of the problem, only limited treatment options are available today. The …
A brief history of hair cell regeneration research and speculations on the future
EW Rubel, SA Furrer, JS Stone - Hearing research, 2013 - Elsevier
Millions of people worldwide suffer from hearing and balance disorders caused by loss of
the sensory hair cells that convert sound vibrations and head movements into electrical …
the sensory hair cells that convert sound vibrations and head movements into electrical …
The challenge of hair cell regeneration
AK Groves - Experimental Biology and Medicine, 2010 - journals.sagepub.com
Sensory hair cells of the inner ear are responsible for translating auditory or vestibular
stimuli into electrical energy that can be perceived by the nervous system. Although hair …
stimuli into electrical energy that can be perceived by the nervous system. Although hair …
[HTML][HTML] Hair Cell Regeneration: From Animals to Humans
Cochlear hair cells convert sound into electrical signals that are relayed via the spiral
ganglion neurons to the central auditory pathway. Hair cells are vulnerable to damage …
ganglion neurons to the central auditory pathway. Hair cells are vulnerable to damage …
Comparing sensory organs to define the path for hair cell regeneration
Deafness or hearing deficits are debilitating conditions. They are often caused by loss of
sensory hair cells or defects in their function. In contrast to mammals, nonmammalian …
sensory hair cells or defects in their function. In contrast to mammals, nonmammalian …
[PDF][PDF] Hair cell regeneration: an exciting phenomenon… but will restoring hearing and balance be possible?
JI Matsui, BM Ryals - Journal of Rehabilitation Research & …, 2005 - researchgate.net
Sensory hair cells of the inner ear are susceptible to damage from a variety of sources
including aging, genetic defects, and environmental stresses such as loud noises or …
including aging, genetic defects, and environmental stresses such as loud noises or …
Hair cell regeneration
Y Chen, S Zhang, R Chai, H Li - Hearing loss: Mechanisms, prevention …, 2019 - Springer
Cochlear hair cells are mechanoreceptors of the auditory system and cannot spontaneously
regenerate in adult mammals; thus hearing loss due to hair cell damage is permanent. In …
regenerate in adult mammals; thus hearing loss due to hair cell damage is permanent. In …
Hair cell regeneration
ASB Edge, ZY Chen - Current opinion in neurobiology, 2008 - Elsevier
The mammalian inner ear largely lacks the capacity to regenerate hair cells, the sensory
cells required for hearing and balance. Recent studies in both lower vertebrates and …
cells required for hearing and balance. Recent studies in both lower vertebrates and …
[HTML][HTML] Stem cell-based hair cell regeneration and therapy in the inner ear
J Qi, W Huang, Y Lu, X Yang, Y Zhou, T Chen… - Neuroscience …, 2024 - Springer
Hearing loss has become increasingly prevalent and causes considerable disability, thus
gravely burdening the global economy. Irreversible loss of hair cells is a main cause of …
gravely burdening the global economy. Irreversible loss of hair cells is a main cause of …