In vitro and in vivo models: What have we learnt about inner ear regeneration and treatment for hearing loss?

MP Lee, J Waldhaus - Molecular and Cellular Neuroscience, 2022 - Elsevier
The sensory cells of the inner ear, called hair cells, do not regenerate spontaneously and
therefore, hair cell loss and subsequent hearing loss are permanent in humans. Conversely …

Novel insights into inner ear development and regeneration for targeted hearing loss therapies

M Roccio, P Senn, S Heller - Hearing research, 2020 - Elsevier
Sensorineural hearing loss is the most common sensory deficit in humans. Despite the
global scale of the problem, only limited treatment options are available today. The …

A brief history of hair cell regeneration research and speculations on the future

EW Rubel, SA Furrer, JS Stone - Hearing research, 2013 - Elsevier
Millions of people worldwide suffer from hearing and balance disorders caused by loss of
the sensory hair cells that convert sound vibrations and head movements into electrical …

The challenge of hair cell regeneration

AK Groves - Experimental Biology and Medicine, 2010 - journals.sagepub.com
Sensory hair cells of the inner ear are responsible for translating auditory or vestibular
stimuli into electrical energy that can be perceived by the nervous system. Although hair …

[HTML][HTML] Hair Cell Regeneration: From Animals to Humans

SW Choi, JM Abitbol, AG Cheng - Clinical and Experimental …, 2024 - synapse.koreamed.org
Cochlear hair cells convert sound into electrical signals that are relayed via the spiral
ganglion neurons to the central auditory pathway. Hair cells are vulnerable to damage …

Comparing sensory organs to define the path for hair cell regeneration

N Denans, S Baek, T Piotrowski - Annual review of cell and …, 2019 - annualreviews.org
Deafness or hearing deficits are debilitating conditions. They are often caused by loss of
sensory hair cells or defects in their function. In contrast to mammals, nonmammalian …

[PDF][PDF] Hair cell regeneration: an exciting phenomenon… but will restoring hearing and balance be possible?

JI Matsui, BM Ryals - Journal of Rehabilitation Research & …, 2005 - researchgate.net
Sensory hair cells of the inner ear are susceptible to damage from a variety of sources
including aging, genetic defects, and environmental stresses such as loud noises or …

Hair cell regeneration

Y Chen, S Zhang, R Chai, H Li - Hearing loss: Mechanisms, prevention …, 2019 - Springer
Cochlear hair cells are mechanoreceptors of the auditory system and cannot spontaneously
regenerate in adult mammals; thus hearing loss due to hair cell damage is permanent. In …

Hair cell regeneration

ASB Edge, ZY Chen - Current opinion in neurobiology, 2008 - Elsevier
The mammalian inner ear largely lacks the capacity to regenerate hair cells, the sensory
cells required for hearing and balance. Recent studies in both lower vertebrates and …

[HTML][HTML] Stem cell-based hair cell regeneration and therapy in the inner ear

J Qi, W Huang, Y Lu, X Yang, Y Zhou, T Chen… - Neuroscience …, 2024 - Springer
Hearing loss has become increasingly prevalent and causes considerable disability, thus
gravely burdening the global economy. Irreversible loss of hair cells is a main cause of …