Methods to evaluate maternal-fetal transport across the placental barrier have generally
involved clinical observations after-the-fact, ex vivo perfused placenta studies, or in vitro …

Optimal development of the embryo and the fetus depends on placental passage of gases,
nutrients, hormones, and waste products. These molecules are transferred across the …

In the past few decades, the placenta became a very controversial topic that has had many
researchers and pharmacists discussing the significance of the effects of pharmaceutical …

The current lack of knowledge about the effect of maternally administered drugs on the
developing fetus is a major public health concern worldwide. The first critical step toward …

The human placenta expresses a large number of transport proteins. The ATP-binding
cassette (ABC) family of active efflux pumps, predominantly localised to the maternal-facing …

Quantification of fetal drug exposure remains challenging since sampling from the placenta
or fetus during pregnancy is too invasive. Currently existing in vivo (eg, cord blood sampling) …

Although various drugs, environmental pollutants and nanoparticles (NP) can cross the
human placental barrier and may harm the developing fetus, knowledge on predictive …

The early‐stage placental barrier is characterized by a lack of fetal circulation and by a thick
trophoblastic barrier, whereas the later‐stage placenta consists of vascularized chorionic …

INTRODUCTION: The placental barrier (PB) is the thin biological membrane made of
endothelial cells (EC), trophoblast cells (TC) and basal membrane that separates between …

The human placental barrier facilitates many key functions during pregnancy, most notably
the exchange of all substances between the mother and fetus. However, preclinical models …