The cellular and molecular basis of major depressive disorder: towards a unified model for understanding clinical depression

E Pitsillou, SM Bresnehan, EA Kagarakis… - Molecular biology …, 2020 - Springer
Major depressive disorder (MDD) is considered a serious public health issue that adversely
impacts an individual's quality of life and contributes significantly to the global burden of …

[HTML][HTML] Molecular pathways of major depressive disorder converge on the synapse

GR Fries, VA Saldana, J Finnstein, T Rein - Molecular Psychiatry, 2023 - nature.com
Major depressive disorder (MDD) is a psychiatric disease of still poorly understood
molecular etiology. Extensive studies at different molecular levels point to a high complexity …

Linking molecules to mood: new insight into the biology of depression

V Krishnan, EJ Nestler - American Journal of Psychiatry, 2010 - Am Psychiatric Assoc
Major depressive disorder is a heritable psychiatric syndrome that appears to be associated
with subtle cellular and molecular alterations in a complex neural network. The affected …

Pathogenesis of depression: insights from human and rodent studies

C Ménard, GE Hodes, SJ Russo - Neuroscience, 2016 - Elsevier
Major depressive disorder (MDD) will affect one out of every five people in their lifetime and
is the leading cause of disability worldwide. Nevertheless, mechanisms associated with the …

[HTML][HTML] Major depression: one brain, one disease, one set of intertwined processes

EV Filatova, MI Shadrina, PA Slominsky - Cells, 2021 - mdpi.com
Major depressive disorder (MDD) is a heterogeneous disease affecting one out of five
individuals and is the leading cause of disability worldwide. Presently, MDD is considered a …

[HTML][HTML] Major depressive disorder: existing hypotheses about pathophysiological mechanisms and new genetic findings

M Kamran, F Bibi, A ur. Rehman, DW Morris - Genes, 2022 - mdpi.com
Major depressive disorder (MDD) is a common mental disorder generally characterized by
symptoms associated with mood, pleasure and effectiveness in daily life activities. MDD is …

[HTML][HTML] Epigenetic modifications of major depressive disorder

K Saavedra, AM Molina-Márquez, N Saavedra… - International journal of …, 2016 - mdpi.com
Major depressive disorder (MDD) is a chronic disease whose neurological basis and
pathophysiology remain poorly understood. Initially, it was proposed that genetic variations …

[PDF][PDF] Current understanding of the neurobiology of major depressive disorder

AL Chiriţă, V Gheorman, D Bondari, I Rogoveanu - Rom J Morphol Embryol, 2015 - rjme.ro
Depression is highly prevalent worldwide and associated with significant morbidity and
mortality. Approximately 340 million people worldwide suffer from depression at any given …

Molecular aspects of depression: a review from neurobiology to treatment

GRV Boas, RB de Lacerda, MM Paes, P Gubert… - European journal of …, 2019 - Elsevier
Major depressive disorder (MDD), also known as unipolar depression, is one of the leading
causes of disability and disease worldwide. The signs and symptoms are low self‑esteem …

The molecular neurobiology of depression

RC Shelton - Psychiatric Clinics of North America, 2007 - Elsevier
The molecular neurobiology of depression begins with the concept that depressive
disorders represent a family of related but distinct conditions. Different points of vulnerability …