Psychological mechanisms and functions of 5-HT and SSRIs in potential therapeutic change: Lessons from the serotonergic modulation of action selection, learning …
Uncertainty regarding which psychological mechanisms are fundamental in mediating SSRI
treatment outcomes and wide-ranging variability in their efficacy has raised more questions …
treatment outcomes and wide-ranging variability in their efficacy has raised more questions …
Serotonin and brain function: a tale of two receptors
RL Carhart-Harris, DJ Nutt - Journal of psychopharmacology, 2017 - journals.sagepub.com
Previous attempts to identify a unified theory of brain serotonin function have largely failed to
achieve consensus. In this present synthesis, we integrate previous perspectives with new …
achieve consensus. In this present synthesis, we integrate previous perspectives with new …
Modulation of anxiety behaviors by 5-HT-interacting drugs
FS Guimarães, AP Carobrez, FG Graeff - Handbook of Behavioral …, 2008 - Elsevier
Results gathered in the last 35 years clearly show that serotonin (5-HT) is involved in
anxiety. In agreement with this proposal, serotonin selective reuptake inhibitors (SSRIs) are …
anxiety. In agreement with this proposal, serotonin selective reuptake inhibitors (SSRIs) are …
A mechanistic account of serotonin's impact on mood
Selective serotonin reuptake inhibitors (SSRIs) constitute a first-line antidepressant
intervention, though the precise cognitive and computational mechanisms that explain …
intervention, though the precise cognitive and computational mechanisms that explain …
Beyond negative valence: 2-week administration of a serotonergic antidepressant enhances both reward and effort learning signals
To make good decisions, humans need to learn about and integrate different sources of
appetitive and aversive information. While serotonin has been linked to value-based …
appetitive and aversive information. While serotonin has been linked to value-based …
Do dorsal raphe 5-HT neurons encode “beneficialness”?
Abstract The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) affects numerous
behavioral and physiological processes. Drugs that alter 5-HT signaling treat several major …
behavioral and physiological processes. Drugs that alter 5-HT signaling treat several major …
The 5-HT2A serotonin receptor in executive function: Implications for neuropsychiatric and neurodegenerative diseases
S Aznar, MES Hervig - Neuroscience & Biobehavioral Reviews, 2016 - Elsevier
Executive function entails the interplay of a group of cognitive processes enabling the
individual to anticipate consequences, attain self-control, and undertake appropriate goal …
individual to anticipate consequences, attain self-control, and undertake appropriate goal …
Enhanced 5-HT1A receptor-dependent feedback control over dorsal raphe serotonin neurons in the SERT knockout mouse
M Soiza-Reilly, NM Goodfellow, EK Lambe… - …, 2015 - Elsevier
HT1A receptors are widely expressed in the brain and play a critical role in feedback
inhibition of serotonin (5-HT) neurons through multiple mechanisms. Yet, it remains poorly …
inhibition of serotonin (5-HT) neurons through multiple mechanisms. Yet, it remains poorly …
Serotoninergic regulation of emotional and behavioural control processes
5-Hydroxytryptamine (5-HT, serotonin) has long been implicated in a wide variety of
emotional, cognitive and behavioural control processes. However, its precise contribution is …
emotional, cognitive and behavioural control processes. However, its precise contribution is …
Translating the promise of 5HT4 receptor agonists for the treatment of depression
Animal experimental studies suggest that 5-HT4 receptor activation holds promise as a
novel target for the treatment of depression and cognitive impairment. 5-HT4 receptors are …
novel target for the treatment of depression and cognitive impairment. 5-HT4 receptors are …