Serotonin is an influential monoamine neurotransmitter that signals through a number of
receptors to modulate brain function. Among different serotonin receptors, the serotonin 1A …

Serotonin (5-HT) deficiency is a core biological pathology underlying depression and other
psychiatric disorders whose key symptoms include decreased motivation. However, the …

Abstract Serotonin (5-HT) dysfunction has been involved in both movement and behavioral
disorders. Serotonin pharmacology improves dyskinetic movements as well as depressive …

Several lines of evidence implicate serotonin (5-hydroxytryptamine, 5-HT) in regulating
personality traits and mood control. Serotonergic neurons are classically thought to be tonic …

Serotonin (5-HT) regulates attention by neurobiological mechanisms that are not well
understood. Layer 6 (L6) pyramidal neurons of prefrontal cortex play an important role in …

Selective serotonin (5-HT) reuptake inhibitors (SSRIs) are first-line antidepressants but
require several weeks to elicit their actions. Chronic SSRI treatment induces desensitization …

Disruptions in the cortico-limbic emotion regulation networks have been linked to
depression, anxiety, impulsivity, and aggression. Altered transmission of the central nervous …

Medium spiny neurons (MSNs) constitute 95% of neurons in the dorsal striatum subdivided
into direct (striatonigral) and indirect (striatopallidal) pathways. Whereas D 1 and D 2 …

Background The central neuromodulator serotonin (5-HT) has been implicated in a wide
range of behaviors and affective disorders, but the principles underlying its function remain …

Major depression is a chronic, recurring and potentially life-threatening illness that affects up
to 10% of the population worldwide. Pharmacological and genetic studies highlight the …