The complexities of the involvement of the serotonin transmitter system in numerous
biological processes and psychiatric disorders is, to a substantial degree, attributable to the …

Hypofunction of the serotonergic system is often associated with major depression and
obsessive compulsive disorder (OCD). Selective serotonin reuptake inhibitors (SSRIs) are …

Rationale LSD is the prototypical psychedelic. Despite a clear central role of the 5HT2a
receptor in its mechanism of action, the contributions of additional receptors for which it …

The 5-HT3 receptor is a ligand-gated ion channel expressed on interneurons throughout the
brain. So far, analysis of the 5-HT3A knockout mouse revealed changes in nociceptive …

Moncrieff and colleaguesL umbrella review [1] offers an opportunity to reflect on the
'Serotonin hypothesisL of depression serendipitously developed 50 years ago. The notion …

Selective serotonin (5-HT) re-uptake inhibitors (SSRIs) are commonly used in the treatment
of generalized anxiety disorder in Humans. However, because only few animal models …

It is firmly believed that the mechanism of action of SSRIs in major depression is to inhibit the
serotonin transporter, SERT, and increase extracellular concentration of serotonin. However …

Psychiatric disorders, particularly depression and anxiety, are often associated with
impaired serotonergic function. However, serotonergic interventions yield inconsistent …

Major depressive disorder (MDD) is the most prevalent mental illness contributing to global
disease burden. Selective serotonin (5-HT) reuptake inhibitors (SSRIs) are the first-line …

The development of social behavior is strongly influenced by the serotonin system.
Serotonin 2c receptor (5-HT2cR) is particularly interesting in this context considering that …