Abstract The serotonin (5-HT) 6 receptor is a Gs-coupled receptor exclusively expressed in
the central nervous system. Highest receptor densities are found in brain regions implicated …

We use the knockout mice strategy to investigate the contribution of the 5-HT1B receptor in
mediating the effects of selective serotonin reuptake inhibitors (SSRI). Using microdialysis in …

The enhancement of central serotonin system function underlies the therapeutic effects of
selective serotonin reuptake inhibitors (SSRIs), which have become the most commonly …

The therapeutic effects induced by serotonin-selective reuptake inhibitor (SSRI)
antidepressants are initially triggered by blocking the serotonin transporter and rely on long …

A disturbance in 5-HT signalling can lead to maladaptive and disruptive behavioural
changes seen in neuropsychiatric disorders, potentially by 5-HT's role in cognitive control …

Abstract Neurotransmission by serotonin (5-HT) is tightly regulated by several autoreceptors
that fine-tune serotonergic neurotransmission through negative feedback inhibition at the …

Serotonin (5-HT) shapes brain networks during development and modulates a wide
spectrum of essential neuronal functions ranging from perception and cognitive appraisal to …

The fact that selective serotonin reuptake inhibitors (SSRIs) have antidepressant effects in
some patients supports the notion that serotonin plays a role in the mode of action of …

Background Less than half of patients with major depressive disorder (MDD) respond to
their first antidepressant trial. Our understanding of the underlying mechanisms of selective …

Serotonergic agents have been widely used for treatment of psychiatric disorders, but the
therapeutic effects are insufficient and these drugs often induce severe side effects. We …