Adenyl cobamide (commonly known as pseudovitamin B12) is synthesized by intestinal
bacteria or ingested from edible cyanobacteria. The effect of pseudovitamin B12 on the …

1. To examine possible regulatory roles of liver and kidney in cobalamin metabolism,
specific activities of the two cobalamin-dependent enzymes, uptake in vivo of cyano [57Co] …

We have investigated the uptake and metabolism of free cyanocobalamin (CN-Cbl; vitamin
B 12) by intact cultured human skin fibroblasts. Monolayers of control fibroblasts take up free …

Vitamin B 12-coenzyme levels have been measured in the liver, kidney, and brain of normal
and vitamin B 12-deficient rats, and in the liver, kidney, and heart of deficient and …

There are 2 currently known enzymes in humans that utilize vitamin B-12 as a cofactor—
namely, cytoplasmic methionine synthase and mitochondrial methylmalonyl-CoA mutase …

Cobalamin, commonly known as vitamin B 12, is an essential micronutrient for humans
because of its role as an enzyme cofactor. Cobalamin is one of over a dozen structurally …

ABSTRACT Vitamin B-12 (cobalamin) deficiency results in decreased L-methylmalonyl-
coenzyme A (CoA) mutase activity. The consequence of this defect on the cellular CoA pool …

Vitamin B12-deficient rats were used to study the effects of feeding vitamin B12 on hepatic
methylmalonyl-CoA mutase activity, which was decreased by the deficiency. A significant …

Abstract Mouse fibroblast (L-929) cells, in culture, synthesized and secreted into the growth
medium a vitamin B 12-binding substance which was identical to mouse transcobalamin II …

Intact fibroblasts from children with vitamin B12 dependent methylmalonicaciduria failed to
isomerize methylmalonate to succinate, and contained less than 10 percent of the normal …