Severely vitamin B-12 (B-12)–deficient rats were produced by feeding a B-12–deficient diet.
The status of B-12 deficiency was confirmed by an increase in urinary methylmalonate …

Selected residues in a highly conserved 15-residue region, 174SVDTAAMAGLAFTC L188
of human transcobalamin (TC), a cobalamin (Cbl: vitamin B12) binding protein, were …

Abstract Transcobalamin II (TC II) was purified about 300, 000-fold from Cohn fraction III
using a modification of the procedure described by Allen and Majerus (J. Biol. Chem. 247 …

Cobalamin (Cbl)? is well known as a unique vitamin in having a red color, the highest
molecular weight (CN-Cbl, 1355.5) among vitamins and a complicated structure with a …

Assay of the reactivity between the chicken anti-rabbit transcobalamin II antiserum and the
sera of 19 vertebrate species was carried out by both immunodiffusion and Sephadex G-200 …

Smith and Monty (1959) have presented substantial evidence that the activity of
methylmalonyl-CoA isomerase (Beck, Flavin and Ochoa 1957, Beck and Ochoa 1958) is …

Background: Accurate assessment of cobalamin profiles in human serum, cells, and tissues
may have clinical diagnostic value. However, non-alkyl forms of cobalamin undergo β-axial …

Cyanocobalamin (CNCbl) and aquo/hydroxocobalamin (HOCbl) are the forms of vitamin
B12 that are most commonly used for supplementation. They are both converted to …

Recent studies have isolated and characterized human gastric intrinsic factor (IF) and
transcobalamin II (TC II) genes, whose products mediate the import of cobalamin (Cbl; …

We have examined the effect of addition of hydroxocobalamin to growth medium on the
activity of the adenosylcobalamin-requiring enzyme methylmalonyl CoA mutase in normal …