In the rat heart, there is a remarkable remodeling due to catecholamines. As to the functional
effects, norepinephrine (NE) induced a marked positive chronotropic effect and an elevation …

Cardiac hypertrophy and failure were induced in male Wistar rats by daily administration of 5
mg/kg isoproterenol for three weeks. Age-matched animals were used as normal control. To …

It is known that the heart will adapt to actual demand by increasing or decreasing its size
through different mechanisms. In this presentation, the possible role of catecholamines in …

Continuous intravenous infusion of norepinephrine norepinephrine (NE, 0.1 mg/kg/h)
induced hypertrophy of the left ventricle (LV), but not of the right ventricle (RV) in rats …

The aim of the study was to assess the relationships between oxidative stress, cardiac
remodelling and fibrosis on an experimental model of heart failure with adrenergic …

Abstract Sprague Dawley male rats (200–220 g) were subjected to a long-term treatment
with low doses of catecholamines in an attempt to assess the effect of the adrenergic …

Catecholamine-induced myocardial hypertrophy and necrosis in rats have been measured
and compared following treatment with different catecholamines. Significant degrees of both …

Objective: In this study we have tested the hypothesis that degradation of collagen by matrix
metalloproteinase 2 (MMP-2) precedes the deposition of extracellular matrix (ECM) after …

An observation published by our group in 1969 has lead to a continuing series of studies
into the mechanisms of norepinephrine (NE) induced hypertrophy (1). We observed that …

The increase in norepinephrine (NE) blood levels in human heart failure correlates with
prognosis. In this study, we determined whether continuous NE infusion alters the positive …