Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common
form of clonal mosaicism,,,–, yet our knowledge of the causes and consequences of this is …

Incidence and mortality for sex-unspecific cancers are higher among men, a fact that is
largely unexplained,. Furthermore, age-related loss of chromosome Y (LOY) is frequent in …

To the Editor—Recent studies have found associations between loss of chromosome Y
(LOY) in leukocytes and an increased risk for all-cause mortality1 as well as various …

The Y chromosome is frequently lost in hematopoietic cells, which represents the most
common somatic alteration in men. However, the mechanisms that regulate mosaic loss of …

Mosaic loss of chromosome Y (mLOY) is frequently observed in the leukocytes of ageing
men. However, the genetic architecture and biological mechanisms underlying mLOY are …

Studies in recent years have revealed that increasing age is associated with the
accumulation of post-zygotic genetic aberrations in different cell lineages even in the …

The prevalence of highly repetitive sequences within the human Y chromosome has
prevented its complete assembly to date and led to its systematic omission from genomic …

Many human Y-chromosomal deletions are thought to severely impair reproductive fitness,
which precludes their transmission to the next generation and thus ensures their rarity in the …

Mosaic loss of chromosome Y (LOY) in leukocytes is the most common form of clonal
mosaicism, caused by dysregulation in cell-cycle and DNA damage response pathways …

Mosaic loss of the Y chromosome (mLOY) in peripheral leukocytes is a somatic event in
which a fraction of leukocytes have lost the entire Y chromosome. The frequency of mLOY …