Background: Polyamines and nitric oxide (NO) have been involved in the pathogenesis of
cardiac hypertrophy. NO can regulate cardiac ion channels by direct actions on G-proteins …

Cardiac muscle hypertrophy is one of the most important compensatory responses of the
heart to multiple stresses that may be placed on it. If the stress is not relieved, sustained …

Ornithine decarboxylase (ODC), the rate-limiting enzyme in the biosynthesis of polyamines,
displays high activity early in postnatal development of the heart, followed by a gradual …

Ornithine decarboxylase activity in rat heart was increased significantly by the injection of l-
norepinephrine or nisoxetine, an inhibitor of norepinephrine uptake. The enzyme was also …

Both ornithine decarboxylase (ODC) and nitric oxide synthase (NOS) activities rely on the
availability of the common substrate L-arginine, which is directly processed by NOS to nitric …

DFMO is a selective irreversible inhibitor of ornithine decarboxylase (ODC), the initial
enzyme in the polyamine biosynthetic pathway. DFMO was utilized to determine the role of …

Background/Aims: Studies performed in experimental animals have shown that polyamines
contribute to several physiological and pathological processes, including cardiac …

Polyamines (putrescine, spermidine, and spermine) play an essential role in cell growth,
differentiation, and apoptosis. Protein kinase C (PKC) stimulates polyamine biosynthesis …

Ornithine decarboxylase, a possible rate-limiting enzyme in the synthesis of polyamines,
was assayed in hearts of normal rats, sham-operated rats, and rats subjected to aortic …

The activity of rat heart ornithine decarboxylase (ODC), the enzyme involved in the initial
step of polyamine biosynthesis, was markedly stimulated after isoproterenol treatment …