In the following investigation, we have studied the role of polyamines in the regulation of
atrial natriuretic peptide (ANP) using ventricular cardiocytes which in culture synthesize and …

Ca2+ signaling plays a fundamental role in cardiac hypertrophic remodeling, but the
underlying mechanisms remain poorly understood. We investigated the role of Ca2+ …

The Na+/K+-ATPase inhibitor ouabain has been shown to trigger hypertrophic growth of
cultured cardiomyocytes; however, the significance of endogenous ouabain-like compound …

ABSTRACT Omithine decarboxylase(ODC; EC 4.1. 1.17) is an important enzyme in the
synthesis of polyamines and is assoaated with growth and differentiation. Insulin stimulation …

The effect of β-and α-adrenergic stimulation on cardiovascular function and development of
cardiac hypertrophy was studied in rats by measuring the heart weight/body weight and …

Study objective–The aim of the study was to investigate adrenaline synthesis in atrial and
ventricular homogenates. Design–The study involved the use of a new assay which …

Phenylephrine and noradrenaline (α-adrenergic agonism) or isoprenaline (β-adrenergic
agonism) stimulated protein synthesis rates, increased the activity of the atrial natriuretic …

Mammalian atrial myocytes secrete a potent natriuretic and diuretic factor, atrial natriuretic
peptide (ANP), in response to volume expansion or elevations of right atrial pressure. ANP is …

Polyamines mediate acute metabolic effects and cardiac hypertrophy associated with β-
adrenoceptor stimulation. They may also modulate β-adrenoceptors, causing functional …

The effect of the putative mitochondrial KATP channel opener diazoxide (100 μM) was
studied in terms of its ability to modulate the hypertrophic effect of 24 h treatment with the α1 …