While a number of factors may initiate structural alterations within the cardiovascular system
in response to hypertension, there are obligate cellular signaling mechanisms, such as the …

The polyamines are essential cellular components for growth. Control of a key regulated
enzyme of polyamine biosynthesis, ornithine decarboxylase (ODC), as a function of growth …

Imidazoline receptors are divided into I1 and I2 subtypes. I1-imidazoline receptors are
distributed in the heart and are upregulated during hypertension or heart failure. The aim of …

The present study was designed to provide a better understanding of the role played by
AdoMetDC (S-adenosylmethionine decarboxylase), the key rate-controlling enzyme in the …

The polyamines are a family of low-molecular-weight organic cations that play essential
intracellular regulatory roles in cell growth and differentiation. Elevations in cellular …

There is strong evidence about the importance of catecholamines and calcium signaling in
heart function. Also, interaction of these two systems is well documented. Catecholamines …

Background Adenosine is an important regulator of many cardiac functions and is
synthesized primarily by ecto-and cytosolic 5′-nucleotidase. We have previously reported …

Norepinephrine (NE) causes hypertrophic growth of cardiac myocytes via stimulation of
alpha1-adrenergic receptors (α1-AR). Reactive oxygen species (ROS) can act as signaling …

cAMP responsive element binding protein (CREB) is a stimulus induced transcription factor
with possible relevance for the pathophysiology of the heart. In the present study, we provide …

Renal hypertrophy and hyperfiltration are early manifestations of human and experimental
diabetes that may contribute to the late development of diabetic nephropathy. The …