In the isolated perfused rat hearts, the activity of tissue ornithine decarboxylase gradually
decreases over 90 min. In contrast, the activity of S-adenosylmethionine decarboxylase …

Myocardial ornithine decarboxylase activity has been measured in the right and left
ventricles of rats subjected to hypobaric conditions. Control normobaric groups included …

Treatment with thyroxine for 7 days to produce myocardial hypertrophy led to an increase in
the content of putrescine, spermidine, and spermine in the rat heart. The content of …

Chronic administration of norepinephrine for 8 weeks has been shown to reduce neuronal
norepinephrine uptake activity and increase interstitial norepinephrine concentration in the …

Reactive oxygen species (ROS) play a crucial role in various physiological and pathological
processes mediated by β-adrenergic receptors (β-ARs) in cardiomyocytes. However, the …

We previously reported that increased type 5 adenylyl cyclase (AC5) expression in AC5
transgenic (Tg) mice enhances chronic catecholamine stress via increases in oxidative …

Angiotensin II (ANG II) has profound effects on the development and progression of
pathological cardiac hypertrophy; however, the intracellular signaling mechanisms are not …

We have investigated and characterized a novel ornithine decarboxylase (ODC) related
protein (ODCrp) also annotated as gm853. ODCrp shows 41% amino acid sequence identity …

Cardiac hypertrophy produced by treatment with thyroxine for 7 days was accompanied by a
significant increase in polyamine content. Putrescine was elevated by 4-to 5-fold …

An antisense oligodeoxynucleotide (ODN) approach was used to investigate whether
mitogen-activated protein kinase (MAPK) is necessary for the hypertrophic response in …