Cytochrome c oxidase subunit IV is essential for assembly and respiratory function of the enzyme complex

Y Li, JS Park, JH Deng, Y Bai - Journal of bioenergetics and …, 2006 - Springer
Cytochrome c oxidase or complex IV, catalyzes the final step in mitochondrial electron
transfer chain, and is regarded as one of the major regulation sites for oxidative …

Assembly of mitochondrial cytochrome c-oxidase, a complicated and highly regulated cellular process

F Fontanesi, IC Soto, D Horn… - American Journal of …, 2006 - journals.physiology.org
Cytochrome c-oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain,
plays a key role in the regulation of aerobic production of energy. Biogenesis of eukaryotic …

Role of nuclear-encoded subunit Vb in the assembly and stability of cytochrome c oxidase complex: implications in mitochondrial dysfunction and ROS production

D Galati, S Srinivasan, H Raza, SK Prabu… - Biochemical …, 2009 - portlandpress.com
CcO (cytochrome c oxidase) is a multisubunit bigenomic protein complex which catalyses
the last step of the mitochondrial electron transport chain. The nuclear-encoded subunits are …

Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4, 5a, 6a, 7a and 7b

D Fornuskova, L Stiburek, L Wenchich… - Biochemical …, 2010 - portlandpress.com
Mammalian CcO (cytochrome c oxidase) is a hetero-oligomeric protein complex composed
of 13 structural subunits encoded by both the mitochondrial and nuclear genomes. To study …

The Complexity of Mitochondrial Complex IV: An Update of Cytochrome c Oxidase Biogenesis in Plants

N Mansilla, S Racca, DE Gras, DH Gonzalez… - International journal of …, 2018 - mdpi.com
Mitochondrial respiration is an energy producing process that involves the coordinated
action of several protein complexes embedded in the inner membrane to finally produce …

The subunit composition and function of mammalian cytochrome c oxidase

B Kadenbach, M Hüttemann - Mitochondrion, 2015 - Elsevier
Cytochrome c oxidase (COX) from mammals and birds is composed of 13 subunits. The
three catalytic subunits I-III are encoded by mitochondrial DNA, the ten nuclear-coded …

Human Cytochrome c Oxidase: Structure, Function, and Deficiency

JW Taanman - Journal of bioenergetics and biomembranes, 1997 - Springer
As the terminal component of the mitochondrial respiratory chain, cytochrome c oxidase
plays a vital role in cellular energy transformation. Human cytochrome c oxidase is …

Phosphorylation of Mammalian Cytochrome c and Cytochrome c Oxidase in the Regulation of Cell Destiny: Respiration, Apoptosis, and Human Disease

M Hüttemann, I Lee, LI Grossman, JW Doan… - … Nuclear-Encoded Genes …, 2012 - Springer
The mitochondrial oxidative phosphorylation (OxPhos) system not only generates the vast
majority of cellular energy, but is also involved in the generation of reactive oxygen species …

Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex

N Lenka, C Vijayasarathy, J Mullick… - Progress in nucleic acid …, 1998 - Elsevier
Cytochrome c Oxidase (COX) is the terminal component of the bacterial as well as the
mitochondrial respiratory chain complex that catalyzes the conversion of redox energy to …

The power of life—cytochrome c oxidase takes center stage in metabolic control, cell signalling and survival

S Arnold - Mitochondrion, 2012 - Elsevier
Mitochondrial dysfunction is increasingly recognized as a major factor in the etiology and
progression of numerous human diseases, such as (neuro-) degeneration, ischemia …