Epidemiological distribution of mosaic loss of chromosome Y in adult men in 10 areas in China and its prospective association with lung cancer
YX Zhao, MY Song, J Lyu, CQ Yu, P Pei… - Zhonghua liu Xing …, 2024 - europepmc.org
Objective: To detect the prevalence of mosaic loss of chromosome Y in adult men in ten
study areas in China, describe the epidemiological distribution of mosaic loss of …
study areas in China, describe the epidemiological distribution of mosaic loss of …
Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications
A Bonnefond, B Skrobek, S Lobbens, E Eury… - Nature …, 2013 - nature.com
Large chromosomal clonal mosaic events (CMEs) have been suggested to be linked to
aging,, and to predict cancer,. Type 2 diabetes (T2D) has been conceptualized as an …
aging,, and to predict cancer,. Type 2 diabetes (T2D) has been conceptualized as an …
Multi-ancestry genome-wide association meta-analysis of mosaic loss of chromosome Y in the Million Veteran Program identifies 167 novel loci
Mosaic loss of chromosome Y (mLOY) is a common somatic mutation in leukocytes of older
males. mLOY was detected in 126,108 participants of the Million Veteran Program: 106,054 …
males. mLOY was detected in 126,108 participants of the Million Veteran Program: 106,054 …
Somatic genomic mosaicism & human disease
Somatic genomic mosaicism has become a major focus of genetic research during the last
decade (Campbell et al., 2015; D'Gama and Walsh, 2018). Considering the number of …
decade (Campbell et al., 2015; D'Gama and Walsh, 2018). Considering the number of …
Mosaic Chromosomal Alterations Are Associated With Increased Lung Cancer Risk: Insight From the INTEGRAL-ILCCO Cohort Analysis
Introduction Mosaic chromosomal alterations (mCAs) detected in white blood cells represent
a type of clonal hematopoiesis (CH) that is understudied compared with CH-related somatic …
a type of clonal hematopoiesis (CH) that is understudied compared with CH-related somatic …
Molecular karyotyping of patients with MCA/MR: the blurred boundary between normal and pathogenic variation
TJL De Ravel, I Balikova, B Thienpont… - … and genome research, 2006 - karger.com
Molecular karyotyping has revealed that microdeletions/duplications in the human genome
are a major cause of multiple congenital anomalies associated with mental retardation …
are a major cause of multiple congenital anomalies associated with mental retardation …
Mosaic Chromosomal Alterations and Monoclonal B-Cell Lymphocytosis: Relationship and Risk of Hematologic Malignancies
R Griffin, A Sekar, SA Parikh, G Genovese… - Blood, 2023 - Elsevier
Background: Monoclonal B-cell lymphocytosis (MBL) is a precursor condition to chronic
lymphocytic leukemia (CLL) characterized by the presence of circulating monoclonal B-cell …
lymphocytic leukemia (CLL) characterized by the presence of circulating monoclonal B-cell …