The effect of pH, buffer capacity and ionic strength on quetiapine fumarate release from matrix tablets prepared using two different polymeric blends

R Hamed, R AlJanabi, S Sunoqrot… - Drug Development and …, 2017 - Taylor & Francis
The objective of this study was to investigate the effect of the different physiological
parameters of the gastrointestinal (GI) fluid (pH, buffer capacity, and ionic strength) on the in …

[PDF][PDF] Formulation and evaluation of matrix-based sustained release tablets of quetiapine fumarate and the influence of excipients on drug release

P Gawali, A Gupta, S Kachare, S Kshirsagar - J Chem Pharm Res, 2012 - academia.edu
The aim of the present study was to develop and characterize an oral sustain release drug
delivery system for commonly prescribed antipsychotic Quetiapine fumarate. Hydrophilic …

Influence of HPMC K100LV and Compritol® HD5 ATO on drug release and rheological behavior of HPMC K4M matrix tablets

R Hamed, A Al-Samydai, T Al Baraghthi… - Journal of …, 2017 - Springer
Purpose The objectives of this study were to develop once-a-day oral controlled-release
tablets of quetiapine fumarate (QF) and to determine the effect of polymer type, viscosity …

An understanding of modified release matrix tablets behavior during drug dissolution as the key for prediction of pharmaceutical product performance–Case study of …

P Kulinowski, K Woyna-Orlewicz, GM Rappen… - International Journal of …, 2015 - Elsevier
Motivation for the study was the lack of dedicated and effective research and development
(R&D) in vitro methods for oral, generic, modified release formulations. The purpose of the …

The stability of quetiapine oral suspension compounded from commercially available tablets

J Tran, MA Gervase, J Evans, R Deville, X Dong - PLoS One, 2021 - journals.plos.org
Quetiapine fumarate (QF) is an atypical antipsychotic used off-label for the treatment of
delirium in critically-ill infants and children. For the treatment of pediatric populations or …

Formulation and pharmaceutical development of quetiapine fumarate sustained release matrix tablets using a QbD approach

A Gavan, A Porfire, C Marina, I TOMUŢĂ - Acta Pharmaceutica, 2017 - hrcak.srce.hr
Sažetak The main objective of the present study was to apply QbD methodology in the
development of once-a-day sustained release quetiapine tablets. The quality target product …

Formulation and Evaluation of Gastroretentive Floating Tablets of Quetiapine Fumarate

KS Patel, AN Rao, DR Patel, DM Patel… - Journal of Drug Delivery …, 2021 - jddtonline.info
The objective of the present study was to develop gastroretentive floating tablets of
quetiapine fumarate. The gastroretentive floating tablets of quetiapine fumarate were …

Design, optimization and pharmacokinetics of novel prolonged gastroretentive drug delivery system of quetiapine fumarate

DM Mehta, PB Parejiya, HK Patel, PJ Trivedi… - Journal of …, 2016 - Springer
Present study attempts to overcome pH-dependent solubility, a limitation for oral delivery of
poorly soluble BCS class-II drugs. A pH independent, patient compliant, dual working …

Bioequivalence of two quetiapine extended release tablets in Chinese healthy volunteers under fasting and fed conditions and effects of food on pharmacokinetic …

X Huang, S Zhang, Y Ma, H Yang, C He… - Drug Design …, 2018 - Taylor & Francis
Objective The objectives of this study were to evaluate the bioequivalence of Quesero
extended release (Quesero XR) tablets and Seroquel extended release (Seroquel XR) …

[PDF][PDF] In vitro and in vivo evaluation of quetiapine fumarate controlled gastroretentive floating drug delivery system

AK Babu, MV Ramana - International Journal of Drug Delivery, 2016 - researchgate.net
A bstract The aim of the present work was to develop and optimize gastroretentive floating
system of Quetiapine fumarate (QF) for the effective treatment of Schizophrenia. The present …