Objective: High dosages of catecholamines induce cardiomyocyte necrosis and interstitial
fibrosis in rats. We investigated whether this initial damage is followed by the development …

Chronic isoproterenol administration produces a rapid, highly reproducible rodent model of
cardiac hypertrophy. Yet, despite widespread use of this model, the effects of isoproterenol …

The objective of this study was to determine whether a simple, noninvasive method involving
administration of isoproterenol could be used to produce myocardial injury and cardiac …

To assess the possible contribution of the circulatory and cardiac renin-angiotensin system
(RAS) to the cardiac hypertrophy induced by a β-agonist, the present study evaluated the …

The effect of atorvastatin on cardiac remodeling, function, and homodynamic parameters in
isoproterenol-induced heart failure was evaluated in the present study. A subcutaneous …

The purpose of the present study was to gain a better understanding of the relation between
ventricular remodeling and heart failure by assessing the adaptation of the heart through …

This study has administered pirfenidone (5‐methyl‐1‐phenyl‐2‐[1H]‐pyridone) or amiloride
to attenuate the remodelling and associated functional changes, especially an increased …

The isolated rat heart failed to generate contractile force within 10, 15 and 60 min upon
perfusion with medium containing 100, 50 and 20 mg/l oxidized isoproterenol respectively …

Objectives: To investigate the effects of aldosterone receptor blockade in postinfarction heart
failure. Methods: Eighty-seven rats with moderate myocardial infarction were randomized to …

From pharmacological investigations and clinical studies, it is known that angiotensin
converting enzyme (ACE) inhibitors exhibit additional local actions, which are not related to …