Background Mosaic loss of Y chromosome (LOY) is the most common chromosomal
alteration in aging men. Here, we use single-cell RNA and ATAC sequencing to show that …

Background End-stage renal failure is associated with profound changes in physiology and
health, but the molecular causation of these pleomorphic effects termed “uremia” is poorly …

Background The lifelong accumulation of somatic mutations underlies age-related
phenotypes and cancer. Mutagenic forces are thought to shape the genome of aging cells in …

The integration of single cell transcriptome and chromatin accessibility datasets enables a
deeper understanding of cell heterogeneity. We performed single nucleus ATAC (snATAC …

Background Cell type-specific transcriptional programming results from the combinatorial
interplay between the repertoire of active regulatory elements. Disease-associated variants …

Cell-lineage–specific transcripts are essential for differentiated tissue function, implicated in
hereditary organ failure, and mediate acquired chronic diseases. However, experimental …

Nephrons scar and involute during aging, increasing the risk of chronic kidney disease. Little
is known, however, about genetic mechanisms of kidney aging. We sought to define the …

Mosaic loss of chromosome Y (mLOY) is frequently observed in the leukocytes of ageing
men. However, the genetic architecture and biological mechanisms underlying mLOY are …

Background Mosaic loss of chromosome Y (LOY) in leukocytes is the most prevalent somatic
aneuploidy in aging humans. Men with LOY have increased risks of all-cause mortality and …

Several studies show evidence for the genetic basis of renal disease, which renders some
individuals more prone than others to accelerated renal aging. Studying the genetics of …