It has long been established that individuals with anxiety disorders tend to overgeneralize
attributes of fearful stimuli to nonfearful stimuli, but there is little mechanistic understanding …

The persistent intrusion of remote traumatic memories in people with post-traumatic stress
disorder (PTSD) may contribute to the impairment of their ongoing hippocampal and …

Learning locations of danger within our environment is a vital adaptive ability whose neural
bases are only partially understood. We examined fMRI brain activity while participants …

The generalization of fear is an adaptive, behavioral, and physiological response to the
likelihood of threat in the environment. In contrast, the overgeneralization of fear, a cardinal …

In recent studies, inactivation of the dorsal hippocampus before the retrieval of extinguished
fear memories disrupted the context-dependent expression of these memories. In the …

Although temporo-parietal cortices mediate spatial navigation in animals and humans, the
neural correlates of reward-based spatial learning are less well known. Twenty-five healthy …

Emotional arousal induced by stress and/or anxiety can exert complex effects on learning
and memory processes in mammals. Recent studies have begun to link study of the …

Hippo campal impairments are reliably associated with post-traumatic stress disorder
(PTSD); however, little research has characterized how increased threat sensitivity may …

We investigated the neural bases of navigation based on spatial or sequential egocentric
representation during the completion of the starmaze, a complex goal-directed navigation …

Humans, like other animals, alter their behavior depending on whether a threat is close or
distant. We investigated spatial imminence of threat by developing an active avoidance …