A review of interventions against fetal alcohol spectrum disorder targeting oxidative stress

Y Zhang, H Wang, Y Li, Y Peng - International Journal of Developmental …, 2018 - Elsevier
Introduction Fetal alcohol spectrum disorder is caused by maternal ethanol exposure; it
causes physical, behavioral, cognitive, and neural impairments (Murawski et al., 2015) …

Advances in the development of novel antioxidant therapies as an approach for fetal alcohol syndrome prevention

X Joya, O Garcia‐Algar, J Salat‐Batlle… - … Research Part A …, 2015 - Wiley Online Library
Ethanol is the most common human teratogen, and its consumption during pregnancy can
produce a wide range of abnormalities in infants known as fetal alcohol spectrum disorder …

Vitamin E protects against alcohol-induced cell loss and oxidative stress in the neonatal rat hippocampus

MD Marino, MY Aksenov, SJ Kelly - International Journal of Developmental …, 2004 - Elsevier
Oxidative stress has been proposed as a possible mechanism underlying nervous system
deficits associated with Fetal Alcohol Syndrome (FAS). Current research suggests that …

[HTML][HTML] The Fetal Alcohol Spectrum Disorders—An Overview of Experimental Models, Therapeutic Strategies, and Future Research Directions

M Król, P Skowron, K Skowron, K Gil - Children, 2024 - mdpi.com
Since the establishment of a clear link between maternal alcohol consumption during
pregnancy and certain birth defects, the research into the treatment of FASD has become …

Ethanol exposure during development, and brain oxidative stress

J Gil-Mohapel, CD Bianco, PA Cesconetto… - Neuroscience of …, 2019 - Elsevier
Ethanol exposure during pregnancy can produce a variety of central nervous system
abnormalities in the offspring, resulting in a broad spectrum of cognitive and behavioral …

Vitamin E and β-carotene protect against ethanol combined with ischemia in an embryonic rat hippocampal culture model of fetal alcohol syndrome

JJ Mitchell, M Paiva, MB Heaton - Neuroscience letters, 1999 - Elsevier
Neurodevelopmental damage can occur as a result of in utero exposure to alcohol.
Oxidative stress processes are one of many proposed mechanisms thought to contribute to …

[HTML][HTML] Epigallocatechin gallate ameliorates the effects of prenatal alcohol exposure in a fetal alcohol spectrum disorder-like mouse model

L Almeida-Toledano, V Andreu-Fernández… - International Journal of …, 2021 - mdpi.com
Fetal alcohol spectrum disorder is the main preventable cause of intellectual disability in the
Western world. Although binge drinking is the most studied prenatal alcohol exposure …

The preventive effect of oral EGCG in a fetal alcohol spectrum disorder mouse model

L Long, Y Li, YD Wang, QY He, M Li… - Alcoholism: Clinical …, 2010 - Wiley Online Library
Background: Fetal alcohol spectrum disorder (FASD) is a challenging public health problem.
Previous studies have found an association between FASD and oxidative stress. In the …

Ascorbic acid inhibits ROS production, NF-κB activation and prevents ethanol-induced growth retardation and microencephaly

Y Peng, KHH Kwok, PH Yang, SSM Ng, J Liu… - …, 2005 - Elsevier
In this study, we established an embryo model to study the effects of ethanol on fetal
development. When embryos of Xenopus laevis (the African clawed frog) were exposed to …

[HTML][HTML] Fetal alcohol spectrum disorder (FASD) associated neural defects: complex mechanisms and potential therapeutic targets

P Muralidharan, S Sarmah, FC Zhou, JA Marrs - Brain sciences, 2013 - mdpi.com
Fetal alcohol spectrum disorder (FASD), caused by prenatal alcohol exposure, can result in
craniofacial dysmorphism, cognitive impairment, sensory and motor disabilities among other …