Pharmacokinetic, pharmacodynamic and biodistribution following oral administration of nanocarriers containing peptide and protein drugs

BT Griffin, J Guo, E Presas, MD Donovan… - Advanced Drug Delivery …, 2016 - Elsevier
The influence of nanoparticle (NP) formulations on the pharmacokinetic, pharmacodynamic
and biodistribution profiles of peptide-and protein-like drugs following oral administration is …

Oral nanomedicine approaches for the treatment of psychiatric illnesses

TJ Dening, S Rao, N Thomas, CA Prestidge - Journal of Controlled Release, 2016 - Elsevier
Psychiatric illnesses are a leading cause of disability and morbidity globally. However, the
preferred orally dosed pharmacological treatment options available for depression, anxiety …

Pharmacokinetics, metabolism, distribution and permeability of nanomedicine

S Ravindran, JK Suthar, R Rokade… - Current drug …, 2018 - ingentaconnect.com
Background: Medical application of nanotechnology is termed as Nanomedicine and is
widely used in healthcare industries. Nanotechnology has helped Physicians, Scientists and …

[HTML][HTML] Challenges in development of nanoparticle-based therapeutics

N Desai - The AAPS journal, 2012 - Springer
In recent years, nanotechnology has been increasingly applied to the area of drug
development. Nanoparticle-based therapeutics can confer the ability to overcome biological …

Investigational nanomedicines in 2016: a review of nanotherapeutics currently undergoing clinical trials

JM Caster, AN Patel, T Zhang… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
Nanomedicine is a relatively new field that is rapidly evolving. Formulation of drugs on the
nanoscale imparts many physical and biological advantages. Such advantages can in turn …

Characterization of nanomedicines: A reflection on a field under construction needed for clinical translation success

JB Coty, C Vauthier - Journal of controlled release, 2018 - Elsevier
The nanotechnology revolution offers many expectations for the improvement of medicine
treatments. At present, nanomedicine (NM) development is hampered by methodological …

Considerations when submitting nanotherapeutics to FDA/CDER for regulatory review

K Tyner, N Sadrieh - Characterization of nanoparticles intended for drug …, 2011 - Springer
Abstract The Food and Drug Administration (FDA) does not, as yet, have specific guidances
for products containing nanoscale materials. As announced in the report issued by the FDA …

[HTML][HTML] Nanomedicine for increasing the oral bioavailability of cancer treatments

A Parodi, P Buzaeva, D Nigovora, A Baldin… - Journal of …, 2021 - Springer
Oral administration is an appealing route of delivering cancer treatments. However, the
gastrointestinal tract is characterized by specific and efficient physical, chemical, and …

Bioavailability enhancement strategies: basics, formulation approaches and regulatory considerations

S Beg, S Swain, M Rizwan, M Irfanuddin… - Current Drug …, 2011 - ingentaconnect.com
Poor solubility remains a major challenge for pharmaceutical industry, which is now
considered to be an area of prime importance in the field of biomedical research …

[HTML][HTML] Current hurdles to the translation of nanomedicines from bench to the clinic

S Đorđević, MM Gonzalez, I Conejos-Sánchez… - Drug delivery and …, 2022 - Springer
The field of nanomedicine has significantly influenced research areas such as drug delivery,
diagnostics, theranostics, and regenerative medicine; however, the further development of …