Mitochondrial redox imaging for cancer diagnostic and therapeutic studies

LZ Li, HN Xu, M Ranji, S Nioka… - Journal of innovative …, 2009 - World Scientific
Mitochondrial redox states provide important information about energy-linked biological
processes and signaling events in tissues for various disease phenotypes including cancer …

Quantitative redox imaging biomarkers for studying tissue metabolic state and its heterogeneity

HN Xu, LZ Li - Journal of innovative optical health sciences, 2014 - World Scientific
NAD+/NADH redox state has been implicated in many diseases such as cancer and
diabetes as well as in the regulation of embryonic development and aging. To …

REDOX IMAGING OF THE p53-DEPENDENT MITOCHONDRIAL REDOX STATE IN COLON CANCER EX VIVO

HN Xu, M Feng, L Moon, N Dolloff… - Journal of innovative …, 2013 - World Scientific
The mitochondrial redox state and its heterogeneity of colon cancer at tissue level have not
been previously reported. Nor has how p53 regulates mitochondrial respiration been …

Quantitative mitochondrial redox imaging of breast cancer metastatic potential

HN Xu, S Nioka, JD Glickson… - Journal of biomedical …, 2010 - spiedigitallibrary.org
Predicting tumor metastatic potential remains a challenge in cancer research and clinical
practice. Our goal was to identify novel biomarkers for differentiating human breast tumors …

Quantitative redox scanning of tissue samples using a calibration procedure

HN Xu, B Wu, S Nioka, B Chance… - Journal of innovative …, 2009 - World Scientific
The fluorescence properties of reduced nicotinamide adenine dinucleotide (NADH) and
oxidized flavoproteins (Fp) including flavin adenine dinucleotide (FAD) in the respiratory …

Imaging mitochondrial redox potential and its possible link to tumor metastatic potential

LZ Li - Journal of bioenergetics and biomembranes, 2012 - Springer
Cellular redox states can regulate cell metabolism, growth, differentiation, motility, apoptosis,
signaling pathways, and gene expressions etc. A growing body of literature suggest the …

Optical redox imaging of lonidamine treatment response of melanoma cells and xenografts

HN Xu, M Feng, K Nath, D Nelson, J Roman… - Molecular Imaging and …, 2019 - Springer
Purpose Fluorescence of co-enzyme reduced nicotinamide adenine dinucleotide (NADH)
and oxidized flavoproteins (Fp) provides a sensitive measure of the mitochondrial redox …

FLUORESCENT IMAGES OF MITOCHONDRIAL REDOX STATES IN IN SITU MOUSE HYPOXIC ISCHEMIC INTESTINES

M Ranji, S Nioka, HN Xu, B Wu, LZ Li… - Journal of Innovative …, 2009 - World Scientific
We have imaged mitochondrial oxidation–reduction states by taking a ratio of mitochondrial
fluorophores: NADH (reduced nicotinamide adenine dinucleotide) to Fp (oxidized …

Optical redox imaging indices discriminate human breast cancer from normal tissues

HN Xu, J Tchou, M Feng, H Zhao… - Journal of Biomedical …, 2016 - spiedigitallibrary.org
Our long-term goal was to investigate the potential of incorporating redox imaging technique
as a breast cancer (BC) diagnosis component to increase the positive predictive value of …

Calibration of redox scanning for tissue samples

HN Xu, B Wu, S Nioka, B Chance… - Optical Tomography and …, 2009 - spiedigitallibrary.org
The fluorescence properties of reduced nicotinamide adenine dinucleotide (NADH) and
oxidized flavoproteins (Fp) such as flavin adenine dinucleotide (FAD) in the respiratory …