Background: Long-term antidepressant use has increased exponentially, though this is not
always according to guidelines. Our previous randomized controlled trial (RCT) showed that …

We now recognise that withdrawal symptoms from antidepressants are common, and can be
severe and long-lasting in some people. Many withdrawal symptoms overlap with symptoms …

Understanding the particular pharmacology of different antidepressant drugs can help
explain their adverse effects when they are discontinued. For all antidepressant drugs …

Depressive disorders require long-term treatment with antidepressants, psychotherapy, or
both. The goal of antidepressant therapy is complete remission of symptoms and return to …

To minimize the symptoms of antidepressant discontinuation, gradual tapering is necessary
for all serotonin reuptake inhibitors (SRIs) except fluoxetine, which has an extended half-life …

Strong evidence supports the existence of a discontinuation syndrome following the
withdrawal of antidepressant medication, particularly second-generation antidepressants …

Withdrawal reactions when coming off antidepressants have long been neglected or
minimised. It took almost two decades after the selective serotonin reuptake inhibitors …

Stopping antidepressants can be challenging due to the high rate of discontinuation
symptoms. Patients with antidepressant discontinuation syndrome (ADS) commonly …

Some studies, while they inform us, nonetheless raise more questions than they answer. In
this issue, Baldessarini et al. present provocative information for both clinicians and …

In England, the prescribing of antidepressants, primarily the newer generation
antidepressant classes, has steadily increased over recent years. There is ongoing debate …