Sir, Having shown that clozapine induces a discontinuation syndrome in rats (Goudie et al.,
1999), some years ago we reviewed the clinical significance of this syndrome (Goudie …

Depression is increasingly recognized as a highly recurrent and potentially chronic illness
that imposes a substantial burden on individuals, families, and society. Evidence indicates …

Discontinuation reactions are a group of characteristic physical and psychological symptoms
that commence shortly after stopping or, less commonly, after reducing the dose of an …

Background Antidepressant discontinuation symptoms are becoming an increasingly
important part of clinical practice, but the incidence of antidepressant discontinuation …

OBJECTIVE: The primary objective of this article is to review the literature regarding the
speed of response to antidepressant drugs and potential strategies to accelerate the …

Objective Rapid discontinuation of some psychotropic medications is followed by
discontinuation symptoms as well as an increased risk of early illness recurrence …

Background Several long‐term double‐blind placebo controlled trials have shown
prophylactic antidepressant therapy in unipolar depression. The goal of this work was to …

Discontinuation symptoms are recognised with tricyclic antidepressants, monoamine
oxidase inhibitors, selective serotonin reuptake inhibitors (SSRIs) and miscellaneous …

Introduction Prescription rates for antidepressants (ADs) are high and continue to increase,
despite evidence of significant adverse effects, including withdrawal symptoms, and …

Objective Tapering of selective serotonin reuptake inhibitor (SSRI) therapy, as opposed to
abrupt discontinuation, has been recommended by several guidelines and in the literature in …