Abstract The substantive delay (often 4–6 weeks) between the commencement of an
antidepressant and any discernible improvement in depressive symptoms is an ongoing …

Objective: To review the proposition that antidepressants have a delayed onset of action by
employing measurement and analytic strategies that overcome problems confounding …

BackgroundIn previous research, lapses in dosing of paroxetine or sertraline were
associated with significantly more discontinuation symptoms and deterioration of depressive …

Because the value of antidepressants is hampered by their delay in onset of action,
considerable attention has been focused on developing a drug that acts more rapidly …

The aim of this article is to discuss the validity of relapse prevention trials and the issue of
withdrawal confounding in these trials. Recommendations for long-term antidepressant …

Background Factors influencing antidepressant treatment discontinuation are poorly
understood. In the present study, we aimed to estimate the prevalence of antidepressant …

The issues of timing in antidepressant treatment are of great theoretical and practical
relevance, even more so since recent meta-analyses yielded no evidence for a specific …

Background Several national guidelines include recommendations for a minimum duration
of antidepressant treatment, but these vary from 4–9 months after remission. We aimed to …

The purpose of this article is to review current literature relating to the determination of the
time course of antidepressant effects. Further, this work explores studies examining the …

Background Antidepressants are established as an evidence-based, guideline-
recommended treatment for Major Depressive Disorder. Prescriptions have markedly …