p53 gene mutations are common in uterine serous carcinoma and occur early in their pathogenesis.

H Tashiro, C Isacson, R Levine… - The American journal …, 1997 - ncbi.nlm.nih.gov
Uterine serous carcinoma (USC) is an uncommon but aggressive type of endometrial cancer
associated with rapid progression of disease and a poor prognosis. Both USC and its …

Early uterine serous carcinoma: clonal origin of extrauterine disease

RN Baergen, CD Warren, C Isacson… - International journal of …, 2001 - journals.lww.com
Uterine serous carcinoma (USC) is an uncommon but aggressive type of endometrial
carcinoma that is frequently associated with extrauterine disease despite minimal or no …

Endometrial glandular dysplasia with frequent p53 gene mutation: a genetic evidence supporting its precancer nature for endometrial serous carcinoma

L Jia, Y Liu, X Yi, A Miron, CP Crum, B Kong… - Clinical Cancer …, 2008 - AACR
Abstract Purpose: Endometrial glandular dysplasia (EmGD) has been recently proposed to
be a putative precursor to endometrial serous carcinoma (ESC). The purpose of this study is …

Uterine papillary serous carcinoma evolves via a p53-driven pathway

UM Moll, E Chalas, M Auguste, D Meaney, J Chumas - Human pathology, 1996 - Elsevier
Uterine papillary serous carcinoma (UPSC) is a highly aggressive type of endometrial
cancer that occurs in the absence of hyperestrogenism and endometrial hyperplasia …

p53 immunostaining as a significant adjunct diagnostic method for uterine surface carcinoma: precursor of uterine papillary serous carcinoma

W Zheng, R Khurana, S Farahmand… - The American journal …, 1998 - journals.lww.com
Uterine papillary serous carcinoma (UPSC) is a biologically aggressive carcinoma that
causes a disproportionate number of endometrial cancer deaths because of its dismal …

p53 overexpression and bcl-2 persistence in endometrial carcinoma: comparison of papillary serous and endometrioid subtypes

W Zheng, P Cao, M Zheng, EE Kramer, TA Godwin - Gynecologic oncology, 1996 - Elsevier
Forty-two cases, including 21 uterine papillary serous carcinomas (UPSC) and 21 age-,
nuclear-grade-, and clinical-stage-matched uterine endometrioid carcinomas (UEC), were …

The biological and clinical value of p53 expression in pelvic high‐grade serous carcinomas

M Köbel, A Reuss, A Bois, S Kommoss… - The Journal of …, 2010 - Wiley Online Library
Studies on the p53 expression and outcome for women with ovarian carcinoma have
produced conflicting results. The observed heterogeneity may be due to the range of cut‐offs …

[HTML][HTML] p53 overexpression in morphologically ambiguous endometrial carcinomas correlates with adverse clinical outcomes

K Garg, MM Leitao Jr, CA Wynveen, GL Sica, J Shia… - Modern Pathology, 2010 - Elsevier
The distinction between uterine serous and endometrioid carcinomas can usually be
achieved by morphologic examination alone. However, there are occasional …

[HTML][HTML] Immunohistochemical profile of endometrial adenocarcinoma: a study of 61 cases and review of the literature

S Kounelis, N Kapranos, E Kouri, D Coppola… - Modern Pathology, 2000 - Elsevier
The differences in immunohistochemical expression of p53, bcl-2, bax, estrogen receptor
(ER), and progesterone receptor (PR) were evaluated in 40 endometrioid and 21 papillary …

Immunohistochemical overexpression of p16 and p53 in uterine serous carcinoma and ovarian high-grade serous carcinoma

AG Chiesa-Vottero, A Malpica… - International journal …, 2007 - journals.lww.com
The immunohistochemical expression pattern of p16 in biopsy samples has been useful as
part of a panel to distinguish adenocarcinomas arising from the endometrium from those …