The effect of palytoxin (PTX) on compound resting potential and compound action potential
of frog sciatic nerve was studied using the sucrose-gap technique. PTX irreversibly …

Palytoxin is a coral toxin that seriously impairs heart function, but its effects on excitation-
contraction (EC) coupling have remained elusive. Therefore, we studied the effects of …

Palytoxin (PTX), isolated from the marine soft coral Palythoa tuberculosa, increases the
cation conductance of human red cell membranes. In the presence of 10 (-10) M PTX and 10 …

Palytoxin causes potassium efflux and sodium influx in all investigated animals cells. Much
evidence points to the sodium pump (Na+/K (+)-ATPase) as the target of the toxin. A …

Palytoxin (PTX) inhibits the (Na++ K+)-driven pump and simultaneously opens channels that
are equally permeable to Na+ and K+ in red cells and other cell membranes. In an effort to …

The plasmalemmal Na+-K+-ATPase (NKA) pump is the receptor for the potent marine toxin
palytoxin (PTX). PTX binds to the NKA and converts the pump into a monovalent cation …

Palytoxin binds to Na/K pumps to generate nonselective cation channels whose pore likely
comprises at least part of the pump's ion translocation pathway. We systematically analyzed …

Palytoxin binds to Na+/K+ pumps in the plasma membrane of animal cells and opens an
electrodiffusive cation pathway through the pumps. We investigated properties of the …

The uptake of 22Na+ and secretion of catecholamines by primary cultures of adrenal
medulla cells under the influence of a variety of agonists and antagonists were determined …

We proposed a reaction model for investigating interactions between K+ and the palytoxin–
sodium–potassium (PTX–Na+/K+) pump complex under conditions where enzyme …