Background The cellular form of FLICE-inhibitory protein (cFLIP) blocks death receptor-
induced apoptosis and has been implicated in tumour progression. cFLIP interacts with …

Introduction: Evasion of apoptosis (programmed cell death) is one of the characteristic
hallmarks of human cancers and may be caused by aberrant expression of antiapoptotic …

Cellular FLIP (c-FLIP), also known as FLICE-inhibitory protein, has been identified as an
inhibitor of apoptosis triggered by engagement of death receptors (DRs) such as Fas or …

The expression levels of caspase-8 inhibitory c-FLIP proteins play an important role in
regulating death receptor-mediated apoptosis, as their concentration at the moment when …

Background Evasion of apoptosis is a hallmark of pancreatic cancer. However, the
underlying mechanisms are still only partly understood and may involve antiapoptotic …

Cellular-FLICE inhibitory protein (c-FLIP) is a key anti-apoptotic regulator that inhibits cell
death mediated by the death receptors Fas, DR4, DR5, and TNF-R1. Three splice variants of …

The anti-apoptotic protein c-FLIP, a catalytically inactive homolog of caspase-8, is an
important regulator of death receptor signaling. Death receptors constitute a subgroup of the …

The caspase-8 inhibitor c-FLIP exists as two splice variants, c-FLIP L and c-FLIP S, with
distinct roles in death receptor signaling. The mechanisms determining their turnover have …

The extrinsic pathway is mediated by death receptors (DRs), including CD95 (APO-1/Fas) or
TRAILR-1/2. Defects in apoptosis regulation lead to cancer and other malignancies. The …

Although DU145 prostate cancer cells are resistant to exogenously applied Fas agonist CH-
11 (anti-Fas monoclonal antibody), Fas-resistance can be overcome using a FasL …