Characterization of the human FLICE‐inhibitory protein locus and comparison of the anti‐apoptotic activity of four different flip isoforms
M Djerbi, T Darreh‐Shori, B Zhivotovsky… - Scandinavian …, 2001 - Wiley Online Library
Death receptor‐mediated apoptosis is involved in the regulation of immune responses and
in the maintenance of immunological tolerance. FLICE‐inhibitory proteins (FLIPs) are …
in the maintenance of immunological tolerance. FLICE‐inhibitory proteins (FLIPs) are …
TCR-mediated up-regulation of c-FLIPshort correlates with resistance toward CD95-mediated apoptosis by blocking death-inducing signaling complex activity
S Kirchhoff, WW Müller, A Krueger… - The Journal of …, 2000 - journals.aai.org
To investigate apoptosis resistance upon restimulation in human peripheral blood T
lymphocytes, we used the following in vitro model. This model represents the main features …
lymphocytes, we used the following in vitro model. This model represents the main features …
[HTML][HTML] Release of c-FLIP brake selectively sensitizes human cancer cells to TLR3-mediated apoptosis
Abstract Toll-like receptor 3 (TLR3) mediates innate immune responses by sensing viral
dsRNA, but also induces apoptosis selectively in cancer cells. Our analysis by …
dsRNA, but also induces apoptosis selectively in cancer cells. Our analysis by …
c-FLIP confers resistance to FAS-mediated apoptosis in anaplastic large-cell lymphoma
MP Oyarzo, LJ Medeiros, C Atwell, M Feretzaki… - Blood, 2006 - ashpublications.org
We hypothesized that inhibition of the FAS-mediated apoptosis pathway by FLICE-like
inhibitory protein (c-FLIP) may contribute to oncogenesis in ALK+ anaplastic large-cell …
inhibitory protein (c-FLIP) may contribute to oncogenesis in ALK+ anaplastic large-cell …
[HTML][HTML] Superoxide induced inhibition of death receptor signaling is mediated via induced expression of apoptosis inhibitory protein cFLIP
JL Hirpara, K Subramaniam, G Bellot, J Qu, S Seah… - Redox biology, 2020 - Elsevier
The death inhibitory proteins, cFLIP and Bcl-2, canonically act at different steps to regulate
receptor-mediated apoptosis in cancer cells. Here we report that pharmacological or genetic …
receptor-mediated apoptosis in cancer cells. Here we report that pharmacological or genetic …
Up-regulation of c-FLIPS+R upon CD40 stimulation is associated with inhibition of CD95-induced apoptosis in primary precursor B-ALL
A Troeger, I Schmitz, M Siepermann… - Blood, The Journal …, 2007 - ashpublications.org
Previous studies on apoptosis defects in acute lymphoblastic leukemia (ALL) have focused
on chemotherapy-induced, primarily mitochondrial death pathways. Yet, immunologic …
on chemotherapy-induced, primarily mitochondrial death pathways. Yet, immunologic …
4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells
K Bijangi-Vishehsaraei, MR Saadatzadeh… - Molecular and cellular …, 2010 - Springer
Abstract Cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein (c-FLIP) is a
major resistance factor for the tumor necrosis factor-related apoptosis-inducing ligand TRAIL …
major resistance factor for the tumor necrosis factor-related apoptosis-inducing ligand TRAIL …
[HTML][HTML] Down Regulation of c-FLIPL Enhance PD-1 Blockade Efficacy in B16 Melanoma
Y Wang, J Li, H Ba, K Wang, X Wen, D Li, X Zhu… - Frontiers in …, 2019 - frontiersin.org
Immune checkpoint blockade of programmed cell death protein 1 (PD-1) had an impressive
long-lasting effect in a portion of advanced-stage melanoma patients, however, this therapy …
long-lasting effect in a portion of advanced-stage melanoma patients, however, this therapy …
[PDF][PDF] Co-operative and hierarchical binding of c-FLIP and caspase-8: a unified model defines how c-FLIP isoforms differentially control cell fate
MA Hughes, IR Powley, R Jukes-Jones, S Horn… - Molecular cell, 2016 - cell.com
The death-inducing signaling complex (DISC) initiates death receptor-induced apoptosis.
DISC assembly and activation are controlled by c-FLIP isoforms, which function as pro …
DISC assembly and activation are controlled by c-FLIP isoforms, which function as pro …
E1A Sensitizes Cells to Tumor Necrosis Factor Alpha by Downregulating c-FLIPS
D Perez, E White - Journal of virology, 2003 - Am Soc Microbiol
Tumor necrosis factor alpha (TNF-α) activates both apoptosis and NF-κB-dependent survival
pathways, the former of which requires inhibition of gene expression to be manifested. c …
pathways, the former of which requires inhibition of gene expression to be manifested. c …