Biochemical basis of the antidiabetic activity of oleanolic acid and related pentacyclic triterpenes

JM Castellano, A Guinda, T Delgado, M Rada… - Diabetes, 2013 - Am Diabetes Assoc
Oleanolic acid (OA), a natural component of many plant food and medicinal herbs, is
endowed with a wide range of pharmacological properties whose therapeutic potential has …

The molecular mechanisms underpinning the therapeutic properties of oleanolic acid, its isomer and derivatives for type 2 diabetes and associated complications

D Camer, Y Yu, A Szabo… - Molecular nutrition & food …, 2014 - Wiley Online Library
Recent research has uncovered the molecular mechanisms responsible for the therapeutic
properties of oleanolic acid (OA), its isomer ursolic acid (UA), and derivatives. In particular …

Antidiabetic effect of oleanolic acid: a promising use of a traditional pharmacological agent

X Wang, YL Li, H Wu, JZ Liu, JX Hu… - Phytotherapy …, 2011 - Wiley Online Library
Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia.
Although the clear mechanisms of DM and insulin resistance are still to be cleared, it has …

[HTML][HTML] The role of triterpenes in the management of diabetes mellitus and its complications

J Nazaruk, M Borzym-Kluczyk - Phytochemistry Reviews, 2015 - Springer
Diabetes mellitus is a chronic metabolic disease which is a serious global problem. In 2010
an estimated 285 million people had diabetes and within the next 20 years this value is …

Dietary triterpenes in the treatment of type 2 diabetes: To date

H Teng, B Yuan, S Gothai, P Arulselvan, X Song… - Trends in Food Science …, 2018 - Elsevier
At present, the importance of triterpenes in food and pharmaceutical industries is mainly
based on their potential application in health food and medicine, particularly those …

[HTML][HTML] Oleanolic acid: extraction, characterization and biological activity

JM Castellano, S Ramos-Romero, JS Perona - Nutrients, 2022 - mdpi.com
Oleanolic acid, a pentacyclic triterpenoid ubiquitously present in the plant kingdom, is
receiving outstanding attention from the scientific community due to its biological activity …

[HTML][HTML] Anti-diabetic potential of plant-based pentacyclic triterpene derivatives: Progress made to improve efficacy and bioavailability

M Oboh, L Govender, M Siwela, BN Mkhwanazi - Molecules, 2021 - mdpi.com
Diabetes mellitus (DM) results from the inability of the pancreas to produce sufficient insulin
or weakened cellular response to the insulin produced, which leads to hyperglycemia …

Oleanolic, ursolic, and betulinic acids as food supplements or pharmaceutical agents for type 2 diabetes: promise or illusion?

FSG Silva, PJ Oliveira, MF Duarte - Journal of agricultural and …, 2016 - ACS Publications
Oleanolic (OA), ursolic (UA), and betulinic (BA) acids are three triterpenic acids (TAs) with
potential effects for treatment of type 2 diabetes (T2DM). Mechanistic studies showed that …

[HTML][HTML] In vitro and in vivo antidiabetic potential of monoterpenoids: An update

LT Al Kury, A Abdoh, K Ikbariah, B Sadek, M Mahgoub - Molecules, 2021 - mdpi.com
Diabetes mellitus (DM) is a chronic metabolic condition characterized by persistent
hyperglycemia due to insufficient insulin levels or insulin resistance. Despite the availability …

Oleanolic acid, a natural triterpenoid improves blood glucose tolerance in normal mice and ameliorates visceral obesity in mice fed a high-fat diet

CL de Melo, MGR Queiroz, SGC Fonseca… - Chemico-biological …, 2010 - Elsevier
Excess visceral adiposity may predispose to chronic diseases like hypertension and type 2
diabetes with a high risk for coronary artery disease. Adipose tissue secreted cytokines and …