Nanoparticle oral absorption and its clinical translational potential

KS Kim, K Na, YH Bae - Journal of Controlled Release, 2023 - Elsevier
Oral administration of pharmaceuticals is the most preferred route of administration for
patients, but it is challenging to effectively deliver active ingredients (APIs) that i) have …

[HTML][HTML] Advances in oral drug delivery

MS Alqahtani, M Kazi, MA Alsenaidy… - Frontiers in …, 2021 - frontiersin.org
The oral route is the most common route for drug administration. It is the most preferred
route, due to its advantages, such as non-invasiveness, patient compliance and …

[HTML][HTML] Role of nanostructures in improvising oral medicine

S Ghosh, S Ghosh, PC Sil - Toxicology Reports, 2019 - Elsevier
The most preferable mode of drugs administration is via the oral route but physiological
barriers such as pH, enzymatic degradation etc. limit the absolute use of this route. Herein …

Recent advances in nanocarrier-based mucosal delivery of biomolecules

O Kammona, C Kiparissides - Journal of controlled release, 2012 - Elsevier
This review highlights the recent developments in the area of nanocarrier-based mucosal
delivery of therapeutic biomolecules and antigens. Macromolecular drugs have the unique …

Biopharmaceutical and pharmacokinetic aspects of nanocarrier-mediated oral delivery of poorly soluble drugs

D Babadi, S Dadashzadeh, M Osouli… - Journal of Drug Delivery …, 2021 - Elsevier
Many new chemical entities have limited water solubility and therefore show low and/or
variable oral bioavailability. Among the various strategies to overcome this challenge …

[HTML][HTML] Pharmacokinetic aspects of nanoparticle-in-matrix drug delivery systems for oral/buccal delivery

RC Feitosa, DC Geraldes… - Frontiers in …, 2019 - frontiersin.org
Oral route maintains its predominance among the ones used for drug delivery, especially
when medicines are self-administered. If the dosage form is solid, therapy gains in dose …

Oral delivery of protein-based therapeutics: gastroprotective strategies, physiological barriers and in vitro permeability prediction

L Wright, TJ Barnes, CA Prestidge - International journal of pharmaceutics, 2020 - Elsevier
The number of biological molecules emerging as therapeutics is growing exponentially due
to their higher specificity and tolerability profiles compared to small molecules. Despite this …

The influence of nanoparticle properties on oral bioavailability of drugs

Y Wang, C Pi, X Feng, Y Hou, L Zhao… - International journal of …, 2020 - Taylor & Francis
Oral administration has been the most common therapeutic regimen in various diseases
because of its high safety, convenience, lower costs, and high compliance of patients …

Phytochemical delivery through nanocarriers: A review

R Ahmad, S Srivastava, S Ghosh, SK Khare - Colloids and Surfaces B …, 2021 - Elsevier
In recent times, phytochemicals encapsulated or conjugated with nanocarriers for delivery to
the specific sites have gained considerable research interest. Phytochemicals are mostly …

Striving towards the perfect in vitro oral drug absorption model

JP Gleeson, F McCartney - Trends in pharmacological sciences, 2019 - cell.com
Oral drug delivery systems have multiple goals, assessing and enabling intestinal
absorption at efficacious doses being one of them. Here we highlight the in vitro advances in …