Abstract The PI3K/AKT/mTOR pathway is one of the most commonly disrupted signaling
pathways that plays a role in the development and pathogenicity of multiple cancers …

Phosphatidylinositol 3-kinase α (PI3Kα) is an attractive target for anticancer drug design.
Liphagal, isolated from the marine sponge Aka coralliphaga, possesses the special …

Natural products (NPs) are a rich source of drug discovery, and some of them act by
covalently binding to the targets. Recently, targeted covalent natural product (TCNP) design …

Background: Cholangiocarcinoma (CC) is highly resistant to chemotherapy and radiation,
and is, therefore, difficult to cure. Polo-like kinases (Plks) are increasingly recognized as key …

Polo-like kinase 1, an important enzyme with diverse biological actions in cell mitosis, is a
promising target for developing novel anticancer drugs. A combined molecular docking …

Objective: The polo-like kinase 1 (plk1) plays important roles in the regulation of mitotic
progression, including mitotic entry, spindle formation, chromosome segregation and …

In recent years, derivatives of natural compounds are synthesized to increase the
bioavailability, pharmacology, and pharmacokinetics properties. The naphthoquinone …

Globally, cancer is the second leading cause of mortality and morbidity. The growth and
development of cancer are extremely complex. It is caused by a variety of pathways and …

Molecular modeling studies were carried out on a series of benzimidazole and imidazo [1, 2-
a] pyridines as Plk1 inhibitors. Based on the pharmacophore model, we obtained a five …

Abstract Polo-like kinase 1 (PLK1) is an essential mitotic checkpoint protein that plays a key
role in cell cycle division. Overexpression of PLK1 has been associated with poor prognosis …