Polo-like kinases (Plks) are a family of serine/threonine kinases with a highly conserved N-
terminal Ser/Thr kinase catalytic domain and a C-terminal region that play crucial roles in …

PKP1 has been crucially involved in enhancing the MYC translation leading to lung
carcinogenesis via evading numerous tumour-suppressing checkpoint systems. Plakophilin …

A series of novel pteridinone derivatives possessing a hydrazone moiety were designed,
synthesized and evaluated for their biological activity. Most of the synthesized compounds …

The family of Polo-like kinases is important in the regulation of mitotic progression; this work
keys on one member, namely Polo-like kinase 4 (PLK4). PLK4 has been identified as a …

Polo-like kinase 1 (PLK1) is a serine/threonine protein kinase and plays a critical role in
mitosis. PLK1 has also been regarded as a valuable target for cancer treatment, and several …

Polo‐like kinase 1 (Plk1), a master regulator of mitosis and the DNA damage response, is
considered to be an intriguing target in the research field of mitotic intervention. The …

The fact that viruses cause human cancer dates back to the early 1980s. By reprogramming
cellular signaling pathways, viruses encoded protein that can regulate altered control of cell …

Among the most well-known members of the mitotic protein kinase family are polo-like
kinases. Polo-like kinase 4 as a type of this family is used as a therapeutic target in the …

Abstract Cheliensisin A (Chel A), a styryl-lactone compound extracted from Goniothalamus
cheliensis, is reported to have significant anti-cancer effects in various cancer cells. Here we …

Abstract Dieckol [C 36 H 22 O 18], is a naturally occurring phlorotannin found in some brown
algal species. Dieckol is gaining more attention in the scientific community for its potential …