Renal hypertrophy and hyperfiltration are early manifestations of human and experimental
diabetes that may contribute to the late development of diabetic nephropathy. The …

Formation of polyamines has previously been shown to play an important role for initial
kidney growth in experimental diabetes, as treatment of diabetic rats with a selective …

The selective ornithine decarboxylase (ODC) inhibitor difluoromethyl ornithine (DFMO) was
used to investigate the role of polyamines in initial diabetic renal enlargement. ODC activity …

Polyamines are small biogenic molecules that are essential for cell cycle entry and
progression and proliferation. They can also contribute to hypertrophy. The activity of …

An evaluation of the role of polyamines in different models of kidney hypertrophy in mice.
The role of ornithine decarboxylase (ODC) and polyamines in kidney hypertrophy is …

The effects of streptozotocin (SZ)-induced diabetes on renal ornithine decarboxylase (ODC)
activity, the rate-limiting enzyme in polyamine biosynthesis, were studied. Sixteen hours …

To assess the roles of polyamines (putrescine, spermidine, and spermine) and ornithine
decarboxylase (ODC), the rate-limiting enzyme of polyamine synthesis, in the development …

The activity of ornithine decarboxylase, the rate-controlling enzyme in polyamine
biosynthesis, was determined in tissues of normal control rats and rats made diabetic with …

Ornithine decarboxylase (Z,-ornithine carboxylase; EC 4.1. 1.17)(ODC) activity falls to
approximately 30% of the control value in diabetic rat kidney 4 weeks after induction of …

We measured ornithine decarboxylase activity in rat kidneys obtained at various times
following unilateral nephrectomy. The enzyme activity shows a biphasic response during …