The pathological changes in the retinal microvasculature characteristic of diabetic
retinopathy (DR) are the result of chronic exposure to elevated blood glucose. Since glucose …

purpose. The GLUT1 glucose transporter mediates glucose entry into the endothelial cells of
the inner blood–retinal barrier (BRB). In many cell types, exposure to high glucose …

Capillaries in the retina are more susceptible to develop microvascular lesions in diabetes
than capillaries in the embryologically similar cerebral cortex. Because available evidence …

PURPOSE: The GLUT1 glucose transporter is expressed in endothelial and epithelial
barriers, including the retinal capillary endothelium and the retinal pigment epithelium (RPE) …

Neural tissue is entirely dependent on glucose for normal metabolic activity. Since glucose
stores in the brain and retina are negligible compared to glucose demand, metabolism in …

purpose. The purpose of this study was to elucidate in vitro the effect of elevated glucose on
glucose uptake in the cells comprising the inner and outer blood–retinal barriers: human …

The regulation of glucose transporters (GLUT-1 and GLUT-3), in terms of both mRNA and
protein, in human retinal endothelial cells was investigated. The cells responded within 1 h …

In order to understand the molecular basis of glucose regulation supporting visual function,
this study examined the presence of GLUT2, a facilitated-diffusion glucose transporter …

The transport of glucose across the blood‐brain barrier (BBB) is mediated by the high
molecular mass (55‐kDa) isoform of the GLUT1 glucose transporter protein. In this study we …

Microangiopathy is a systemic complication of diabetes that is especially severe in the
retinal microcirculation. The objective of this study was to compare glucose uptake and …