Certain cancer types afflict female and male patients disproportionately. The reasons
include differences in male/female physiology, effect of sex hormones, risk behavior …

To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP
microarray intensity data of 38,303 women from cancer genome-wide association studies …

BY TINA HESMAN SAEY Losing the Y chromosome in blood cells may bring on cancer and
shorten men's lives, new research suggests. By age 70, about 15 percent of men have lost …

We have studied 215 male patients (aged 45–97 years) whose sole cytogenetic abnormality
was clonal loss of the Y chromosome in metaphase cells from unstimulated cultures. The …

Ample evidence exists for shared risk factors for genetic mosaicism and cancer risk as well
as abundant support linking genetic mosaicism in leukocytes to hematologic malignancies …

Mosaic loss of chromosome Y (LOY) in leukocytes is the most common form of clonal
mosaicism, caused by dysregulation in cell-cycle and DNA damage response pathways …

Loss of the Y‐chromosome (LOY) is described as both a normal age‐related event and a
marker of a neoplastic clone in hematologic diseases. To assess the significance of LOY in …

Hematopoietic mosaic loss of Y chromosome (mLOY) has emerged as a potential male‐
specific accelerator of biological aging, increasing the risk of various age‐related diseases …

Mosaic loss of the X chromosome (mLOX) is the most commonly occurring clonal somatic
alteration detected in the leukocytes of women, yet little is known about its genetic …

Background Age-related macular degeneration (AMD) is the leading cause of severe vision
loss in patients over 55 years old in the industrialized world. In the past 20 years …