Introduction Fibromyalgia (FM) is associated with dysfunctional pain modulation
mechanisms, including central sensitization. Experimental pain measurements, such as …

Background. Recently, it has been proposed that fibromyalgia (FM), a chronic widespread
pain syndrome, results from overactive endogenous excitatory pain mechanisms …

To study the characteristics of temporal summation (TS) and conditioned pain modulation
(CPM) in fibromyalgia (FM) patients, we systematically searched Pubmed and EMBASE for …

We have previously shown that fibromyalgia (FMS) patients have enhanced temporal
summation (windup) and prolonged decay of heat-induced second pain in comparison to …

Introduction In chronic pain conditions such as fibromyalgia (FM), pain amplification within
the central nervous system, or “central sensitization,” may contribute to the development and …

Background In healthy individuals slow temporal summation of pain or wind-up (WU) can be
evoked by repetitive heat-pulses at frequencies of≥. 33 Hz. Previous WU studies have used …

Temporal summation of “second pain”(TSSP) is the result of C-fiber-evoked responses of
dorsal-horn neurons, termed “windup”. This phenomenon is dependent on stimulus …

Background Pain is a dynamic phenomenon dependent on the balance of endogenous
excitatory and inhibitory systems, which can be characterized by quantitative sensory …

Temporal summation of “second pain”(TSSP) is considered to be the result of C-fiber-
evoked responses of dorsal horn neurons, termed 'windup'. TSSP is dependent on stimulus …

Temporal summation of second pain (TSSP) results from repetitive stimulation of peripheral
C-fibers (> 0.33 Hz) and is thought to reflect summation mechanisms of dorsal horn neurons …