Recently emerging evidence has indicated surface nanotopography as an important
physical parameter in the stem cell niche for regulating cell fate and behaviors for various …

Surface nanotopographies are an important way of mimicking the stem cell niche on
biomaterial surfaces. Previous studies have focused on the differentiation of stem cells into a …

Efficient control of the self-renewal and pluripotency maintenance of embryonic stem cell
(ESC) is a prerequisite for translating stem cell technologies to clinical applications. Surface …

Understanding of stem cell–surface interactions and, in particular, long-term maintenance of
stem cell pluripotency on well-defined synthetic surfaces is crucial for fundamental research …

Human embryonic stem cells (hESCs) have great potentials for future cell-based
therapeutics. However, their mechanosensitivity to biophysical signals from the cellular …

Substrates used to culture human embryonic stem cells (hESCs) are typically 2-dimensional
(2-D) in nature, with limited ability to recapitulate in vivo-like 3-dimensional (3-D) …

The potential of embryonic stem (ES) cells for both self-renewal and differentiation into cells
of all three germ layers has generated immense interest in utilizing these cells for tissue …

The success of stem cell therapies relies heavily on our ability to control their fate in vitro
during expansion to ensure an appropriate supply. The biophysical properties of the cell …

The maintenance of stem cell pluripotency or stemness is crucial to embryonic development
and differentiation. The mechanical or physical microenvironment of stem cells, which …

Bioengineering approaches to regulate stem cell fates aim to recapitulate the in vivo
microenvironment. In recent years, manipulating the micro-and nano-scale topography of …