We present a brief introduction of loss of Y chromosome (LOY) in blood and describe the
known risk factors for this condition. We then overview the associations between LOY and …

Recent discoveries have shown that harboring cells without the Y chromosome in the
peripheral blood is associated with increased risk for all-cause mortality and disease such …

Mosaic loss of chromosome Y (mLOY) refers to the condition in male individuals in which a
detectable fraction of cells lose the Y chromosome. Prevalent in haematopoietic cells, this …

Y chromosome (ChrY), the male-specific sex chromosome, has been considered as a
genetic wasteland. Aging-related mosaic loss of ChrY (LOY) has been known for more than …

Mosaic loss of the Y chromosome (mLOY) is a common somatic mutation in the blood of
elderly men and several studies have found mLOY in blood cells to be associated with an …

Background Although Y chromosomal genes are involved in male sex development,
spermatogenesis, and height growth, these genes play no role in the survival or mitosis of …

The Y chromosome has long been considered to be a “genetic wasteland” harboring only
few genes essentially involved in male sex development and spermatogenesis. However …

Mosaic loss of Y chromosome (LOY) is assumed to be among the most common acquired
genetic variations in elderly people. Recent studies have linked aging‐related mosaic LOY …

This protocol describes the generation of chimeric mice in which the Y chromosome is
deleted from a proportion of blood cells. This model recapitulates the phenomenon of …

Epidemiological investigations show that mosaic loss of chromosome Y (LOY) in leukocytes
is associated with earlier mortality and morbidity from many diseases in men. LOY is the …