Key Points CH may be associated with broader ill health (worse performance status,
increased and potentially novel comorbidities). Serum interleukin-6 is elevated in people …

Acquired genetic or cytogenetic alterations in a blood stem cell that confer clonal fitness
promote its relative expansion leading to clonal hematopoiesis (CH). Despite a largely intact …

Clonal hematopoiesis (CH) is described as the outsized contribution of expanded clones of
hematopoietic stem and progenitor cells (HSPCs) to blood cell production. The prevalence …

Clonal hematopoiesis (CH) of indeterminate potential (CHIP), defined as the presence of a
somatic mutation in the peripheral blood at a variant allele frequency (VAF)≥ 2%, affects at …

Highlights•Environmental factors influence the development of clonal hematopoiesis.•
Inflammation exerts a strong influence on hematopoietic stem cell biology and may serve as …

Clonally restricted hematopoiesis is a common aging-associated biological state that
predisposes to subsequent development of a hematological malignancy or cardiovascular …

Clonal haematopoiesis (CH) is a common, age-related expansion of blood cells with
somatic mutations that is associated with an increased risk of haematological malignancies …

Clonal hematopoiesis (CH) results from somatic genomic alterations that drive clonal
expansion of blood cells. Somatic gene mutations associated with hematologic …

Clonal haematopoiesis involves the expansion of certain blood cell lineages and has been
associated with ageing and adverse health outcomes,,,–. Here we use exome sequence …

Clonal hematopoiesis (CH) is associated with age and an increased risk of myeloid
malignancies, cardiovascular risk, and all-cause mortality. We tested for CH in a setting …